王显军, 陶小润, 赵世立, 舒俭德, 郑大明, 苏军英, 冯开军, 黄捷通. 被动物Ⅲ度咬伤者联合使用狂犬病疫苗和免疫球蛋白免疫实验研究[J]. 疾病监测, 1998, 13(9): 325-328. DOI: 10.3784/j.issn.1003-9961.1998.9.325
引用本文: 王显军, 陶小润, 赵世立, 舒俭德, 郑大明, 苏军英, 冯开军, 黄捷通. 被动物Ⅲ度咬伤者联合使用狂犬病疫苗和免疫球蛋白免疫实验研究[J]. 疾病监测, 1998, 13(9): 325-328. DOI: 10.3784/j.issn.1003-9961.1998.9.325
Wang Xianjun et al, . A Study on the Post Vaccination and AntibodyResponses and Equine AntiRabies ImmuneGlobulin in Ⅲ WHO Bitten Patients[J]. Disease Surveillance, 1998, 13(9): 325-328. DOI: 10.3784/j.issn.1003-9961.1998.9.325
Citation: Wang Xianjun et al, . A Study on the Post Vaccination and AntibodyResponses and Equine AntiRabies ImmuneGlobulin in Ⅲ WHO Bitten Patients[J]. Disease Surveillance, 1998, 13(9): 325-328. DOI: 10.3784/j.issn.1003-9961.1998.9.325

被动物Ⅲ度咬伤者联合使用狂犬病疫苗和免疫球蛋白免疫实验研究

A Study on the Post Vaccination and AntibodyResponses and Equine AntiRabies ImmuneGlobulin in Ⅲ WHO Bitten Patients

  • 摘要: 按WHO标准选择171例被动物Ⅲ度咬伤者联合使用法国产PVRV和ERIG进行免疫,观察其免疫效果、全身及局部反应,评价其有效性和安全性。结果表明,全身反应发生率为7.60%,PVRV和ERIG局部反应发生率分别为1.30%和10.53%。应用RFFIT动态检测51例患者,第0、7、14和28天的阳性率分别为0%、41.18%、100%和100%,GMT分别为0.03、0.38、118.83和96.29IU。联合使用PVRV和ERIG进行免疫,异常反应少而轻,安全性好;中和抗体免后第14天即达到高峰

     

    Abstract: To evaluate the immumological effect and safety of combined Purified Vero Rabies Vaccine and Equine AntiRabies Immune Globulin,171 bitten human cases in WHO category Ⅲ were treated.The results indicated that the rate of systemic reaction was 7.60%,and the rates of the local reaction of PVRV and ERIG were 1.30% and 10.52% respectively.51 patient blood samples were detected by RFFIT before and after immunisation,the positive rates on day 0,7,14 and 28 were 0%、41.18%、100% and 100% respectvely;GMT were 0.03、0.38、118.83 and 96.29IU respectively.The data showed that there were rare and mild side reaction of the combined immunization,the antibody appeared rapidly post immunization and reached peak on day 14 in the Ⅲ bitten patients.

     

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