吕秋琼, 许文芳. 麻疹患者T淋巴细胞亚群和调节性T淋巴细胞分析[J]. 疾病监测, 2011, 26(7): 516-518. DOI: 10.3784/j.issn.1003-9961.2011.07.005
引用本文: 吕秋琼, 许文芳. 麻疹患者T淋巴细胞亚群和调节性T淋巴细胞分析[J]. 疾病监测, 2011, 26(7): 516-518. DOI: 10.3784/j.issn.1003-9961.2011.07.005
LV Qiu-qiong, XU Wen-fang. Expression of T lymphocyte and regulatory T lymphocyte in patients with measles[J]. Disease Surveillance, 2011, 26(7): 516-518. DOI: 10.3784/j.issn.1003-9961.2011.07.005
Citation: LV Qiu-qiong, XU Wen-fang. Expression of T lymphocyte and regulatory T lymphocyte in patients with measles[J]. Disease Surveillance, 2011, 26(7): 516-518. DOI: 10.3784/j.issn.1003-9961.2011.07.005

麻疹患者T淋巴细胞亚群和调节性T淋巴细胞分析

Expression of T lymphocyte and regulatory T lymphocyte in patients with measles

  • 摘要: 目的 探讨成年人及儿童麻疹患者急性期与恢复期T淋巴细胞及调节性T淋巴细胞表达水平的变化。 方法 成年人及儿童麻疹患者各40例,用流式细胞术分别测定各组出疹期和恢复期患者外周血CD+3总T细胞、CD+4辅助性T细胞(Th)、CD+8细胞毒性T细胞(Tc)及CD+4CD+25调节性T淋巴细胞(Treg)比例。 结果 成年人麻疹患者出疹期较对照期外周血CD+3总T和CD+4Th表达水平降低,CD+4CD+25 Treg表达水平升高,恢复期CD+4Th升高,CD+8Tc降低,CD+4/CD+8比值升高,CD+4CD+25 Treg降低。儿童麻疹患者出疹期较对照组CD+3总T、CD+4Th降低,恢复期较出疹期CD+3总T表达回升。 结论 T淋巴细胞及调节性T淋巴细胞参与成年人及儿童麻疹患者免疫状态的调节,但其表达水平在成年人和儿童中有差异。

     

    Abstract: Objective To understand the changes in T-lymphocyte and regulatory T-lymphocyte expression in adults and children infected with measles in acute and convalescence periods. Methods Forty adults infected with measles and 40 children infected with measles were selected. The proportions of CD+3T cell, CD+4helper T-lymphocyte (Th), CD+8cytotoxic T-lymphocyte (Tc) and CD+4CD+25 regulatory T-lymphocyte (Treg) in their peripheral blood in acute and convalescence periods were determined with flow cytometry assay. Results In adults, the expression of CD+3T cells and CD+4Th declined and the expression of CD+4CD+25 Treg increased in acute period compared with control group, while the expression of CD+4Th increased, the expression of CD+8Tc declined and CD+4/CD+8increased in convalescence period. In children, the expression of CD+3 T cells and CD+4Th declined in acute period compared with control group, and CD+3 T cell increased in convalescence period. Conclusion T-lymphocyte and regulatory T-lymphocyte take part in the regulation of immune state in adults and children infected with measles, but their expressions differ in two groups.

     

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