Abstract:
Objective To understand the epidemiological characteristics of viral encephalitis (VE) in Zibo, Shandong province. Methods The serum and cerebrospinal fluid (CSF) samples from reported VE cases were collected in Zibo from July to October,2010. The laboratory confirmation of these cases was conducted through serological detections of IgM of Japanese encephalitis virus (JEV), echovirus, coxsackie virus (CoxV), herpes simplex virus (HSV) and mumps virus (MV), and the viral nucleic acid detections of the 5 viruses were conducted for partial samples (68 serum samples, 6 CSF samples). Results A total of 304 clinical VE cases were reported, in which, 112 were IgM antibody or RT-PCR positive (36.8%). The most common pathogens were echovirus and CoxV (totally 59 cases, 19.4%), followed by JEV (30 cases, 9.9%), MV (15 cases, 4.9%) and HSV (8 cases, 2.6%). Up to 82.5% of the VE cases were children under the age of 15 years. Twenty five Japanese encephalitis cases (83.3%) occurred in age group ≥40 years. The reported Japanese encephalitis (JE) cases mainly occurred in September and October (23 cases, 70.7%). Conclusion The overall incidence of VE was 7.7/lakh in Zibo, and the incidence of JE was 0.8/lakh, the disease mainly occurred in adults.
下载: