Abstract: Objective To understand the epidemiological characteristics of hemorrhagic fever with renal syndrome (HFRS) in Tianjin from 2000 to 2011 and provide scientific evidence for prevention and control for the disease. Methods Descriptive epidemiological analysis was conducted on the surveillance data of HFRS in Tianjin during this period. Results A total of 1691 HFRS cases, including 25 deaths, were reported with the average annual incidence being 1.53/lakh. The incidence peaked in 2002 and began to decline rapidly in 2003. The incidence in urban area was higher than other areas (χ2=95.482, P=0.000). Most cases were young males and mainly distributed in framers and workers. The disease mainly occurred in spring. Rat density and rat infection rate began to decline obviously in 2004 and remained at low level in recent years. The rat infection rate was positively correlated with the incidence of the disease in human (r=0.886, P=0.000). Conclusion Although the incidence of HFRS remained stable in Tianjin, it is still necessary to conduct the surveillance of this natural focus disease in the future.