Abstract: Objective To understand the epidemiology of tuberculosis (TB) in Tibet and discuss the TB prevention and control strategy. Methods Descriptive epidemiological analysis was conducted on the TB surveillance data in Tibet in 2010 collected from Tibet TB reporting information system. Results In 2010, a total of 3884 new TB cases were registered, the registering rate of new TB cases was 129.4/lakh, a decline of 11.4% compared with 2009. Most TB cases were detected due to the medical care seeking for illness. TB occurred all the year around, but the incidence peaked during March-April. Most cases were young male adults of Tibetan, their average age was 40.24?0.53 years (PPConclusion The incidence of TB was in decline in Tibet. It is necessary to strengthen the active detection of TB because most cases were detected in hospital visit. The health education about TB prevention and control should be enhanced in Tibetan, young adults, farmers and males as well as students and floating population.