Abstract: Proteus mirabilis is an important opportunistic pathogen, which can cause various infections, especially the severe and refractory urinary tract infection. In recent years, reports about drug resistance of P. mirabilis increased and the drug resistance is more serious. This paper summarizes the research progress in antibiotic resistance of P. mirabilis, focusing on the resistance mechanisms to -lactams and quinolones, drug resistant gene type and epidemic situation, clinical infection and treatment, and future situation.