Abstract: Objective To investigate the mortality trends of cervical cancer and corpus uteri cancer in local population in Guangzhou from 2004 to 2013, and provide evidence for the prevention and control of cervical cancer and corpus uteri cancer. Methods The incidence and mortality data of cervical cancer and corpus uteri cancer as well as local population data in Guangzhou from 2004-2013 were collected, the crude incidence/mortality rates, aged standardized incidence rate (AISR) and age standardized mortality rate (ASMR) based on world population were calculated and the incidence and mortality trends were analyzed with Join-point regression program software. Results The world ASIR of cervical cancer and corpus uteri cancer were 9.76/100 000 and 8.54/100 000 respectively, and the world ASMR of cervical cancer and corpus uteri cancer were 1.76/100 000 and 0.95/100 000 respectively during 2004-2013. The medians of the age when diseases occurred were 47 and 52 years. The cervical cancer mortality began to increase from age 30 years, while the corpus uteri cancer mortality began to increase from age 40 years. During the 10 years, the incidences of both cervical cancer and corpus uteri cancer were in increase, the average annual percent change rates were 2.97%(Z=3.134, 95%CI :0.8%-5.2%)and 2.03%(Z=1.804, 95%CI:-0.6%-4.8%) respectively, and the mortalities of both cervical cancer and corpus uteri cancer were in increase too, the average annual increase rates were 3.35% (Z=1.323, 95%CI:-2.4%-9.4%) and 14.33% (Z=4.626, 95%CI: 6.9%-22.2%)respectively. The overall mortality increase rates were 29.49% and 216.28%. Conclusions In Guangzhou, the mortality rate of cervical cancer was higher than that of corpus uteri cancer, but the mortality rate of corpus uteri cancer increased rapidly during 2004-2013. So it is necessary to pay close attention to corpus uteri cancer prevention and control and strengthen the related health education while conducting cervical cancer screening.