Abstract: Objective To understand the performance of prevention and treatment of pulmonary tuberculosis (TB) in non-local residents in different areas in Sichuan during 2010-2014, identify the factors influencing the access to public health service and provide evidence for the improvement of cross-area TB management. Methods The incidence data of TB in non-local residents and in local residents in 21 prefectures (municipality) in Sichuan were collected through Tuberculosis Reporting Information System for quantitative analysis. Results A total of 288 976 and 11 005 active TB cases were registered in local resident population and in non-local residents respectively in Sichuan from 2010 to 2014. The TB cases in non-local residents were mainly from referral (34.03%) and tracing (32.86%). The non-feedback rate, successful referral rate and management rate of 140 TB cases with in-referral were higher than those of 1 142 TB cases with out-referral (P=0.001;P=0.024;P=0.028). The successful referral rate of TB cases in non-local residents was lower than that of TB patients in local residents(2=15.558,P=0.001). The feedback duration was longest for TB cases with out-referral in western area (21 days). The lost rate of newly diagnosed smear positive TB cases after 1 year treatment was higher in non-local residents than in local residents (2=20.372,P=0.001), and the complete rate of treatment rate of TB cases in non-local residents increased during the past 5 years(trend2=7.768,P=0.005). Conclusion The cross-area TB management based on TB information management system is effective in continuous treatment for the TB cases in non-local residents. It is necessary to improve the supervision and collaboration and to strengthen the health education in non-local residents for the prevention and control of TB, especially in western area.