Abstract: Objective To analyze the distribution of malignant tumor deaths and explore the trend of disease burden caused by malignant tumor in Gaomi, Shandong province, from 2005 to 2014, and provide scientific evidence for the prevention and control of malignant tumor. Methods The mortality data of malignant tumor in Gaomi from 2005 to 2014 was analyzed. Results The crude mortality rate of malignant tumor was 164.99/100 000 in Gaomi during this period(214.20/100 000 in males, 115.98/100 000 in females, and the standardized mortality rate was 95.42/100 000 (124.84/100 000 in males, 65.60/100 000 in females); Malignant tumor mortality rate increased with age in people aged 15 years, after the age of 35 years, the mortality rate was higher in males than in females. The first five malignant tumors with high mortality were lung cancer, stomach cancer, liver cancer, esophagus cancer and rectal cancer. The potential years of life lost (PYLL) and work potential years of life lost (WPYLL) caused by malignant tumor were 151 785.00 years, and 71 100.00 years respectively. Conclusion Malignant tumor was the main causes affecting people's health in Gaomi. Appropriate interventions should be taken to reduce the disease burden caused by malignant tumor and improve the people's awareness of prevention and control of malignant tumor.