程琳琳, 杨玉霞, 郭亚琳. 2015年冬至2016年春儿童急性呼吸道感染病毒监测及分析[J]. 疾病监测, 2017, 32(12): 917-921. DOI: 10.3784/j.issn.1003-9961.2017.12.006
引用本文: 程琳琳, 杨玉霞, 郭亚琳. 2015年冬至2016年春儿童急性呼吸道感染病毒监测及分析[J]. 疾病监测, 2017, 32(12): 917-921. DOI: 10.3784/j.issn.1003-9961.2017.12.006
CHENG Lin-lin, YANG Yu-xia, GUO Ya-lin. Viral surveillance for acute respiratory tract infection in children from the winter of 2015 to the spring of 2016[J]. Disease Surveillance, 2017, 32(12): 917-921. DOI: 10.3784/j.issn.1003-9961.2017.12.006
Citation: CHENG Lin-lin, YANG Yu-xia, GUO Ya-lin. Viral surveillance for acute respiratory tract infection in children from the winter of 2015 to the spring of 2016[J]. Disease Surveillance, 2017, 32(12): 917-921. DOI: 10.3784/j.issn.1003-9961.2017.12.006

2015年冬至2016年春儿童急性呼吸道感染病毒监测及分析

Viral surveillance for acute respiratory tract infection in children from the winter of 2015 to the spring of 2016

  • 摘要: 目的 调查2015年冬至2016年春在郑州大学第三附属医院儿科门诊急性呼吸道感染(ARI)患儿病毒病原学情况。方法 收集483例ARI患儿鼻咽部分泌物,采用多重媒介探针熔解曲线分析技术检测流感病毒A、B型,呼吸道合胞病毒A、B型,副流感病毒1~4型,鼻病毒,腺病毒,人偏肺病毒,冠状病毒,人博卡病毒和肠病毒。结果 病毒阳性检出率29.19%(141/483),前4位依次为流感病毒8.49%、副流感病毒5.38%、呼吸道合胞病毒3.93%、鼻病毒2.90%,双重感染1.86%。29 d至6月龄婴儿病毒总检出率高于3~5岁及 6岁组,组间比较差异有统计学意义(2=7.068,P=0.008;2=6.810,P=0.009),乙型流感病毒在1~2岁检出率最高,冠状病毒在29 d至6月龄者检出率最高,男性与女性病毒总检出率差异无统计学意义。呼吸道合胞病毒A型在急性下呼吸道感染阳性率为8.96%,与急性上呼吸道感染比较差异有统计学意义(2=9.042,P=0.003);鼻病毒春季阳性率高于冬季,乙型流感病毒阳性率冬季高于春季,差异有统计学意义(2=4.999,P=0.025;2=6.876,P=0.009),其他呼吸道病毒在冬、春季阳性率差异无统计学意义。结论 儿童ARI病毒阳性率与年龄、季节、感染状况有关,在调查期间流感病毒、副流感病毒、呼吸道合胞病毒和鼻病毒是儿童ARI的主要病毒病原。

     

    Abstract: Objective To investigate the etiological characteristics of acute respiratory tract infection (ARI) in children seeking medical care in the pediatric outpatient department of the Third Affiliated Hospital of Zhengzhou University from the winter of 2015 to the spring of 2016. Methods A total of 483 nasopharyngeal secretion samples were collected from children with ARI for the detections of influenza A and B viruses, respiratory syncytial virus type A and B, parainfluenza virus type 1, 2, 3 and 4, rhinovirus, adenovirus, human metapneumovirus, coronavirus, human bocavirus and enterovirus with multiple media probe melting curve analysis technique.Results The overall detection rate of respiratory viruses was 29.19% (141/483), the detection rate was 8.49% for influenza viruses, 5.38% for parainfluenza viruses, 3.93% for respiratory syncytial viruses, 2.90% for rhinovirus and 1.86% for co-infections. The virus detection rate in age group 29 days to 6 months was higher than those in age groups 3 to 5 years and 6 years, the differences were significant (P 0.05). The detection rate of influenza B virus was highest in age group 1 to 2 years, and the detection rate of coronavirus was highest in age group 29 days to 6 months. There was no significant difference in the total virus detection rate between males and females. The detection rate of respiratory syncytial virus type A in acute lower respiratory tract infection cases was 8.96%, which was significantly different from that of acute upper respiratory tract infection cases (P0.05). The detection rate of rhinovirus was higher in spring than in winter, and the detection rate of influenza B virus was higher in winter than in spring, and the differences were significant (P0.05), but no significant differences were found in the detection rate of other respiratory viruses between winter and spring.Conclusion The detection rate of respiratory infection pathogens in children with ARI was related to age, season and respiratory infection position. During the investigation period, influenza virus, parainfluenza virus, respiratory syncytial virus and rhinovirus were the major pathogens in children with ARI in pediatric outpatients department of the Third Affiliated Hospital of Zhengzhou University.

     

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