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刘文娟, 徐迎春, 宋燕, 伍海燕, 赵红庆, 邢玉芳, 王彦青, 邹晓楠. 2014－2017年烟台市腹泻病患者中致泻性大肠埃希菌的检测与病原特征分析[J]. 疾病监测, 2018, 33(8): 646-648. DOI: 10.3784/j.issn.1003-9961.2018.08.009
引用本文: 刘文娟, 徐迎春, 宋燕, 伍海燕, 赵红庆, 邢玉芳, 王彦青, 邹晓楠. 2014－2017年烟台市腹泻病患者中致泻性大肠埃希菌的检测与病原特征分析[J]. 疾病监测, 2018, 33(8): 646-648. DOI: 10.3784/j.issn.1003-9961.2018.08.009
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Wenjuan Liu, Yingchun Xu, Yan Song, Haiyan Wu, Hongqing Zhao, Yufang Xing, Yanqing Wang, Xiaonan Zou. Pathogenic characteristics of diarrheagenic Escherichia coli detected in diarrhea patients in Yantai, 2014–2017[J]. Disease Surveillance, 2018, 33(8): 646-648. DOI: 10.3784/j.issn.1003-9961.2018.08.009
Citation: Wenjuan Liu, Yingchun Xu, Yan Song, Haiyan Wu, Hongqing Zhao, Yufang Xing, Yanqing Wang, Xiaonan Zou. Pathogenic characteristics of diarrheagenic Escherichia coli detected in diarrhea patients in Yantai, 2014–2017[J]. Disease Surveillance, 2018, 33(8): 646-648. DOI: 10.3784/j.issn.1003-9961.2018.08.009
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2014－2017年烟台市腹泻病患者中致泻性大肠埃希菌的检测与病原特征分析

Pathogenic characteristics of diarrheagenic Escherichia coli detected in diarrhea patients in Yantai, 2014–2017

    摘要
  • 摘要:
    目的 了解烟台市腹泻病患者中致泻性大肠埃希菌（DEC）的感染状况和致病型分布特点，对社区和综合医院中两家哨点医院腹泻门诊的腹泻患者进行DEC监测，为DEC的防治提供依据。
    方法 采用全自动毛细管电泳仪对生化反应符合DEC特征的菌落进行聚合酶链式反应确认，根据5种DEC特征基因，确定型别。
    结果 在1 174例腹泻病患者的粪便中共检出生化反应鉴定为DEC的268株，进行基因确认25株，感染率为2.13%，其中肠聚集性大肠埃希菌（EAEC）15株，占阳性菌株的60.00%，肠产毒性大肠埃希菌8株、肠致病性大肠埃希菌2株、肠出血性大肠埃希菌和肠侵袭性大肠埃希菌均未检出，毒力基因pic占53.33%，20 ~ 44岁年龄组患者检出率最高（64.00%），6 — 10月检出率为84.00%。
    结论 烟台市DEC感染的致病型以EAEC为主，基因型以pic为主，DEC感染年龄主要集中在20 ~ 44岁年龄组，全年均有感染，夏秋季多发，应注意加强季节性防控。

     

    Abstract:
    Objective To investigate the distribution characteristics of diarrheagenic Escherichia coli in the foodborne diseases of Yantai, and provide evidence for the prevention and control of this treatment.
    Methods The suspected diarrheagenic E. coli strains were confirmed by Polymerase Chain Reaction, and the pathogenic types of the diarrheagenic E. coli strains were identified according to the results of virulence genes detection.
    Results A total of 25 strains of diarrheagenic E. coli were detected from the stool samples of 1 174 patients with diarrhea, including 15 strains of enteroaggregative E. coli, 8 strains of enterotoxigenic E. coli, 2 strains of enteropathogenic E. coli, no enterohemorrhagic E. coli and enteroinvasive E. coli strains were detected. The patients infected with diarrheagenic E. coli accounted for 2.13% of the total diarrhea patients. The main pathogenic gene was the pic, accounting for 53.33%. The detection rate in age group 20–24 years was highest (64.00%). The detection rate during June–October was 84.00%.
    Conclusion Enteroaggregative E. coli carrying virulence gene pic was the major pathogen causing diarrhea in Yantai. The disease mainly affected age group 20–44 years. The detection rate of the pathogens was highest in summer and autumn.

     

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