谭小华, 刘美真, 杨宇威, 李柏生, 康敏. 2005-2017年广东省猩红热流行特征分析[J]. 疾病监测, 2019, 34(5): 411-416. DOI: 10.3784/j.issn.1003-9961.2019.05.010
引用本文: 谭小华, 刘美真, 杨宇威, 李柏生, 康敏. 2005-2017年广东省猩红热流行特征分析[J]. 疾病监测, 2019, 34(5): 411-416. DOI: 10.3784/j.issn.1003-9961.2019.05.010
Xiaohua Tan, Meizhen Liu, Yuwei Yang, Baisheng Li, Min Kang. Epidemiological characteristics of scarlet fever in Guangdong province, 2005–2017[J]. Disease Surveillance, 2019, 34(5): 411-416. DOI: 10.3784/j.issn.1003-9961.2019.05.010
Citation: Xiaohua Tan, Meizhen Liu, Yuwei Yang, Baisheng Li, Min Kang. Epidemiological characteristics of scarlet fever in Guangdong province, 2005–2017[J]. Disease Surveillance, 2019, 34(5): 411-416. DOI: 10.3784/j.issn.1003-9961.2019.05.010

2005-2017年广东省猩红热流行特征分析

Epidemiological characteristics of scarlet fever in Guangdong province, 2005–2017

  • 摘要:
    目的分析2005 — 2017年广东省猩红热的流行特征,为防控猩红热提供科学依据。
    方法应用描述性流行病学方法分析国家疾病监测信息报告管理系统中2005 — 2017年广东省猩红热病例时间、地区和人群分布特征;应用Joinpoint软件估计发病率平均年度变化百分比(AAPC),分析猩红热发病趋势;对2017年分离的66株A族β溶血性链球菌(GAS)进行emm基因分型和抗生素敏感性分析。
    结果2005 — 2017年广东省共报告猩红热病例20 157例,年均发病率为1.46/10万,无死亡病例。 发病呈夏、冬两季高发特点;报告发病率高的地区为珠江三角洲地区,病例数占全省的95.79%;病例主要集中在3 ~ 7岁,以托幼儿童、散居儿童和学生为主。 广东省猩红热发病水平总体呈上升趋势,AAPC为26.4%(95%CI:16.9% ~ 36.7%)。 GAS菌株emm基因型别以emm12型为主(65.12%),emm1型次之(32.56%);菌株对红霉素、克林霉素、四环素耐药;对青霉素、头孢噻肟和左旋氧氟沙星均敏感。
    结论2005 — 2017年广东省猩红热发病水平总体呈上升趋势,三间分布特征未见明显变化;当前GAS菌株流行基因型为emm12和emm1,且菌株对青霉素敏感。

     

    Abstract:
    ObjectiveTo analyze the epidemiologic characteristics of scarlet fever from 2005 to 2017, in Guangdong, and provide evidence for prevention and control of scarlet fever.
    MethodsDescriptive epidemiologic analysis was conducted on the spatial, temporal and population distributions of scarlet fever cases reported through national infectious disease reporting and management system in Guangdong from 2005 to 2017. Joinpoint regression software was performed to obtain the average annual percentage changes (AAPC) of incident rates and analyze the incident trends. A total of 66 strains of beta-haemolyticgroup A Streptococcus pyogens (GAS) isolated in 2017 were analyzed through emm typing and antibiotic susceptibility test.
    ResultsA total of 20 157 scarlet fever cases were reported in Guangdong from 2005 to 2017, with the annual incidence rates of 1.46/100 000. More cases were reported in summer and winter. High incidences were reported in Pearl River Delta region, with the proportion of 95.79% to the total cases of the province. Most cases were children aged 3 to 7 years. The proportion of children in kindergarten is the highest, followed by scattered children and students. The incidence of scarlet fever in Guangdong was on the rise, and the AAPC was 26.4% (95%CI: 16.9%–36.7%). The most prevalent emm type of pathogenic bacteria was emm12 (65.12%), followed by emm1 (32.56%). The strains were all resistant to erythromycin, clindamycin and tetracycline, and the bacteria were all sensitive to pencillin, cefotaxime and levofloxacin.
    ConclusionThe incidence of scarlet fever in Guangdong was on the rise, but no obvious change were observed in the epidemiological patterns. The prevalent emm type of GAS was emm12 and emm1, and strains of GAS were sensitive to pencillin.

     

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