刘峰, 李刚, 刘凤仁, 俞国龙. 广东省深圳市首例孕妇感染H9N2禽流感病例流行病学调查[J]. 疾病监测, 2019, 34(7): 621-625. DOI: 10.3784/j.issn.1003-9961.2019.07.010
引用本文: 刘峰, 李刚, 刘凤仁, 俞国龙. 广东省深圳市首例孕妇感染H9N2禽流感病例流行病学调查[J]. 疾病监测, 2019, 34(7): 621-625. DOI: 10.3784/j.issn.1003-9961.2019.07.010
Feng Liu, Gang Li, Fengren Liu, Guolong Yu. Epidemiological survey of the first case of pregnant women infection with avian influenza A (H9N2) virus in Shenzhen[J]. Disease Surveillance, 2019, 34(7): 621-625. DOI: 10.3784/j.issn.1003-9961.2019.07.010
Citation: Feng Liu, Gang Li, Fengren Liu, Guolong Yu. Epidemiological survey of the first case of pregnant women infection with avian influenza A (H9N2) virus in Shenzhen[J]. Disease Surveillance, 2019, 34(7): 621-625. DOI: 10.3784/j.issn.1003-9961.2019.07.010

广东省深圳市首例孕妇感染H9N2禽流感病例流行病学调查

Epidemiological survey of the first case of pregnant women infection with avian influenza A (H9N2) virus in Shenzhen

  • 摘要:
    目的通过对广东省深圳市龙岗区报告的首例孕妇感染H9N2禽流感病例的流行病学调查,探明可能的感染来源,为今后防控H9N2等亚型禽流感疫情积累经验。
    方法2017-2018年采用现场流行病学方法系统收集深圳市龙岗区报告病例的流行病学资料,采集病例、密切接触者和暴露环境等样本;应用抗原检测的方法检测A型流感病毒;应用荧光定量PCR的方法检测禽流感病毒,并进行分型。采用Excel 2019软件对检验结果进行分析。
    结果患者咽拭子H9N2禽流感病毒核酸阳性,确诊为深圳市首例孕妇感染H9N2禽流感病例;8名密切接触者在医学观察期内均未出现流感样症状,流感抗原及禽流感核酸检测均呈阴性;2017年日常监测结果外环境H9病毒亚型阳性率为14.49%,在A型通用阳性中占比达62.69%;本次疫情共采集外环境标本103份,其中A型通用阳性15份,H9亚型阳性9份。
    结论该患者感染来源可能为青峰乳鸽农庄,但也不能排除日常接触禽类制品暴露。深圳禽类市场外环境禽流感病毒污染情况仍然存在,流行季节高危人群仍有暴露感染的可能,需要予以重视。

     

    Abstract:
    ObjectiveTo identify the possible infection source of the first case of pregnant woman infection with avian influenza A (H9N2) virus reported in Longgang district of Shenzhen and provide evidence for the prevention and control of human infection with H9N2 virus in the future.
    MethodsEpidemiological data of the case were collected systematically using field epidemiology method and the samples of case, close contacts and exposure environments were collected from 2017 to 2018. Influenza A virus was detected by using antigen test. The detection and subtyping of avian influenza virus were conducted with fluorescence quantitative PCR. The data was analyzed by using software Excel 2019.
    ResultsThe throat swabs of the case was detected to be H9N2 virus nucleic acid positive and the case was diagnosed as the first pregnant women infection with H9N2 virus in Shenzhen. Eight close contacts showed no influenza -like symptoms during the medical observation period, and the influenza antigen and avian influenza nucleic acid tests were all negative. In 2017, the daily environment surveillance results showed that the positive rate of H9 virus subtype was 14.49%, The H9 virus subtype positive samples accounted for 62.69% in total universal influenza A virus positive samples. A total of 103 environmental samples were collected in the epidemic, in which 15 were universal influenza A virus positive and 9 were influenza A virus subtype H9 positive.
    ConclusionThe infection source might be a pigeon farm, but the exposure to poultry products in daily life could not be excluded. Avian influenza virus contamination still exists in the environment of poultry markets in Shenzhen, suggesting that the population at high risk still might be exposed in epidemic season. It is necessary to pay attention to this problem.

     

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