赖丽金, 尚翠, 韦艳, 李建东. 裂谷热病毒流行特征及遗传进化分析[J]. 疾病监测, 2019, 34(9): 827-834. DOI: 10.3784/j.issn.1003-9961.2019.09.012
引用本文: 赖丽金, 尚翠, 韦艳, 李建东. 裂谷热病毒流行特征及遗传进化分析[J]. 疾病监测, 2019, 34(9): 827-834. DOI: 10.3784/j.issn.1003-9961.2019.09.012
Lijin Lai, Cui Shang, Yan Wei, Jiandong Li. Epidemiologic and phylogenetic analysis on Rift Valley fever virus[J]. Disease Surveillance, 2019, 34(9): 827-834. DOI: 10.3784/j.issn.1003-9961.2019.09.012
Citation: Lijin Lai, Cui Shang, Yan Wei, Jiandong Li. Epidemiologic and phylogenetic analysis on Rift Valley fever virus[J]. Disease Surveillance, 2019, 34(9): 827-834. DOI: 10.3784/j.issn.1003-9961.2019.09.012

裂谷热病毒流行特征及遗传进化分析

Epidemiologic and phylogenetic analysis on Rift Valley fever virus

  • 摘要:
    目的分析裂谷热病毒自发现以来,疫情发生、疫源地分布以及病毒遗传进化和流行特征,为科学防控提供依据。
    方法应用描述性流行病学方法收集、分析裂谷热疫情的流行情况,筛选全球有明确分离时间和地区的病毒的全基因组序列,利用BEAST 2等软件进行系统进化分析。
    结果截止2018年,全球共22个国家报告了裂谷热本地疫情,人间报告病例39 404例,死亡病例2 323例。 共筛选出183条S片段、138条M片段和135条L片段基因序列。 系统进化树显示,裂谷热病毒的S、M和L片段可分为7个基因亚型(A ~ G),A亚型和B亚型是引起3次大流行的主要亚型。 2016年中国发现首例输入性病例,国际跨境传播趋势有所增强。
    结论裂谷热病毒在非洲分布范围广,实际流行形势被明显低估,应加强对该病毒的监测,注重信息收集与发布,提高有关部门和群众的防控意识,保护公民健康。

     

    Abstract:
    ObjectiveTo analyze the genetic evolution and epidemiologic characteristics of Rift Valley fever virus (RVFV) since its discovery and the incidence and geographic distribution of Rift Valley fever (RVF) in the world, and provide evidence for the prevention and control of RVF.
    MethodsDescriptive epidemiological methods were used to collect and analyze the information about epidemic of RVF in the world; whole genomic sequences of viruses with clear isolation time and region were selected, and the BEAST 2 software packages was used for phylogenetic analysis, and the time and space distribution analysis were performed.
    ResultsBy 2018, RVF outbreaks had been reported in 22 countries, a total of 39 404 cases, including 2 323 deaths, had been reported in the world. Whole genomic sequences of 183 S fragments, 138 M fragments, and 135 L fragments of RVFV were selected. Phylogenetic analysis showed that RVFV S, M and L segments can be classified into seven lineages (A–G). Lineage A and B were the main lineages causing three pandemics. Cross border transmission of the virus is in increase, and an imported case from Angola to China was detected in 2016.
    ConclusionRVFV is widely distributed in Africa, but the severity of the virus spread is underestimated. In the context of increasing cross border transmission, it is necessary to strengthen the laboratory and epidemiologic surveillance for RVFV, information collection and release and improve political attention and public awareness for the prevention and control of the disease to protect people's health.

     

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