张莹, 马巍, 李秀维, 王建强, 王海燕, 谷云有, 徐菁. 成年女性甲状腺结节良/恶性检出情况及影响因素研究[J]. 疾病监测, 2022, 37(5): 694-700. DOI: 10.3784/jbjc.202109240519
引用本文: 张莹, 马巍, 李秀维, 王建强, 王海燕, 谷云有, 徐菁. 成年女性甲状腺结节良/恶性检出情况及影响因素研究[J]. 疾病监测, 2022, 37(5): 694-700. DOI: 10.3784/jbjc.202109240519
Zhang Ying, Ma Wei, Li Xiuwei, Wang Jianqiang, Wang Haiyan, Gu Yunyou, Xu Jing. Analysis on detections of benign and malignant thyroid nodules and risk factors in adult women in China[J]. Disease Surveillance, 2022, 37(5): 694-700. DOI: 10.3784/jbjc.202109240519
Citation: Zhang Ying, Ma Wei, Li Xiuwei, Wang Jianqiang, Wang Haiyan, Gu Yunyou, Xu Jing. Analysis on detections of benign and malignant thyroid nodules and risk factors in adult women in China[J]. Disease Surveillance, 2022, 37(5): 694-700. DOI: 10.3784/jbjc.202109240519

成年女性甲状腺结节良/恶性检出情况及影响因素研究

Analysis on detections of benign and malignant thyroid nodules and risk factors in adult women in China

  • 摘要:
      目的   调查我国成年女性甲状腺结节患病情况及良/恶性的检出率,研究影响甲状腺结节分级的危险因素。
      方法   于2018 — 2019年在山东、河南、河北和浙江省随机选择18~60岁妇女进行调查,调查内容包括膳食情况,体格检查,水样、盐样、尿样、血样等样本采集及甲状腺B超检查。 采用描述性研究、单因素logistic 回归和偏比例优势模型分析甲状腺结节检出情况及结节分级的影响因素。
      结果   纳入研究的2 082人,其中无结节[甲状腺影像和数据报告系统(TI-RADS)1级]、良性结节(TI-RADS 2级)、可能是良性结节(TI-RADS 3级)、可疑或很可能是恶性结节(TI-RADS 4或5级)检出率分别为43.32%、21.23%、14.51%、20.94%。 偏比例优势模型结果显示,年龄、超重肥胖、有甲状腺疾病史对甲状腺结节良/恶性分级的影响有统计学意义(P<0.05)。
      结论  年龄增大、超重和肥胖、有甲状腺疾病史是成年女性甲状腺结节良/恶性分级的危险因素,应对老年人、肥胖人群以及有甲状腺病史高危人群的甲状腺结节进行重点筛查。

     

    Abstract:
      Objective   To understand the detections of benign and malignant thyroid nodules and related factors in adult women in China.
      Methods   Women aged 18−60 years were selected randomly in Shandong, Henan, Hebei and Zhejiang provinces for dietary investigation, physical examination, tests of iodine in water, salt, urine and blood, and ultrasonic examination of thyroid gland. The detection of thyroid nodule and related factors were analyzed by descriptive study, univariate Logistic regression analysis and partial proportional odds model.
      Results   A total of 2082 women were included in this study. The detection rates of non-nodule (TI-RADS grade 1), benign nodule (TI-RADS grade 2), possible benign nodule (TI-RADS grade 3), and suspected or highly suspected malignant nodule (TI-RADS grade 4 or 5) were 43.32%, 21.23%, 14.51% and 20.94%, respectively. The results of the partial proportional odds model showed that age, overweight and obesity, and thyroid disease history had significant effects on the thyroid nodule grading (P<0.05).
      Conclusion   Older age, overweight and obesity, and thyroid disease history are the risk factors for thyroid nodule grading in adult women. It is necessary to conduct screening of thyroid nodules in the elderly, obese population and high-risk population with thyroid disease history.

     

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