2017－2021年安徽省麻疹病毒N基因羧基末端基因特征分析

周淑洁; 程晓东; 柴瑜; 张宁; 陈霞; 苏颖; 王慧玲

doi:10.3784/jbjc.202205230233

2017－2021年安徽省麻疹病毒N基因羧基末端基因特征分析

Carboxyl terminal gene of measles virus N gene in Anhui, 2017−2021

摘要

摘要:
目的了解2017—2021年安徽省麻疹病毒N基因羧基末端基因特征。
方法采用反转录聚合酶链式反应（RT-PCR）方法扩增麻疹病毒N基因C末端450个核苷酸片段，对扩增产物进行核苷酸序列测定和基因特征分析。
结果 2017—2021年安徽省监测到47株H1基因型，2株D8基因型，1株B3基因型和15株A基因型。
结论 2017—2018年H1型仍然是安徽省麻疹流行的优势株，2018年后未监测到H1基因型；输入性病例未引起暴发和流行。安徽省需进一步加强病原学鉴定，及时发现输入性麻疹病例并阻断其传播。

Abstract:
Objective To understand the characteristics of the carboxyl terminal gene of measles virus N gene in Anhui Province from 2017 to 2021.
Methods RT-PCR was used to amplify the 450bp fragment of nucleotide in N gene of measles virus. The nucleotide sequence and gene characteristics of the amplified products were analyzed.
Results From 2017 to 2021, 47 measles virus strains of H1 genotype, 2 measles virus strains of D8 genotype, 1 measles virus strain of B3 genotype and 15 measles virus strains of A genotype were detected in Anhui.
Conclusion From 2017 to 2018, H1 genotype was predominant in measles virus strains in Anhui. After 2018, no H1 genotype strain was detected. Imported measles cases caused no epidemics. It is necessary to further strengthen the identification of measles pathogens in Anhui for the timely detection of imported measles cases and stop virus transmission.

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