Abstract: Since late 2019, Coronavirus disease 2019 (COVID-19) has rapidly spread across the world as a new infectious disease, Xinjiang autonomous region has also experienced three epidemic periods. The Epidemic Prevention Leading Group of Xinjiang and Xinjiang Production and Construction Corps established a special supervision group in time to conduct investigation and guide the performance of COVID-19 prevention and control in primary medical institutions, including pre-inspection and triage of fever cases, the use of protective equipment, hand hygiene, and environmental disinfection, to minimize the risk of nosocomial infection, effectively control the epidemic in Xinjiang, and restart the normal production and life.