张建群, 袁士杰, 苗超. 2007-2018年浙江省余姚市沙门菌血清型变迁及耐药分析[J]. 疾病监测, 2020, 35(7): 627-632. DOI: 10.3784/j.issn.1003-9961.2020.07.016
引用本文: 张建群, 袁士杰, 苗超. 2007-2018年浙江省余姚市沙门菌血清型变迁及耐药分析[J]. 疾病监测, 2020, 35(7): 627-632. DOI: 10.3784/j.issn.1003-9961.2020.07.016
Jianqun Zhang, Shijie Yuan, Chao Miao. Serotype changes and drug sensitivity of Salmonella in Yuyao, Zhejiang, 2007–2018[J]. Disease Surveillance, 2020, 35(7): 627-632. DOI: 10.3784/j.issn.1003-9961.2020.07.016
Citation: Jianqun Zhang, Shijie Yuan, Chao Miao. Serotype changes and drug sensitivity of Salmonella in Yuyao, Zhejiang, 2007–2018[J]. Disease Surveillance, 2020, 35(7): 627-632. DOI: 10.3784/j.issn.1003-9961.2020.07.016

2007-2018年浙江省余姚市沙门菌血清型变迁及耐药分析

Serotype changes and drug sensitivity of Salmonella in Yuyao, Zhejiang, 2007–2018

  • 摘要:
    目的了解浙江省余姚市腹泻监测哨点医院腹泻患者沙门菌感染情况、血清型变迁及药物敏感情况,为制订预防措施和临床治疗提供参考依据。
    方法对2007 — 2018年从余姚市腹泻患者中分离出的295株沙门菌进行复苏、血清分型、药敏试验及分析,采用χ2检验对不同年份沙门菌检出率进行比较。
    结果2007 — 2018年余姚市腹泻监测哨点医院腹泻患者沙门菌检出率为8.60%,男女性别比为1.07∶1,各年龄段均可感染沙门菌,以<5岁儿童为主,夏季检出率最高(10.20%),冬季最低(1.64%)。 分为10个群39种血清型,前4位优势血清型分别为4,5,12:i:-沙门菌(24.41%)、鼠伤寒沙门菌(15.25%)、肠炎沙门菌(9.83%)和斯坦利沙门菌(8.14%)。 295株沙门菌对青霉素类、四环素、磺胺甲恶唑耐药率较高,其余均较敏感,2014 — 2018年对头孢类耐药率比2007 — 2013年明显上升;多重耐药菌多集中于优势菌型,共107株(36.27%)。 2007 — 2018年余姚市沙门菌检出率、血清型和耐药性均发生了变迁。 2007 — 2013年检出率低,为3.08%(34/1 103),菌型少,检出14种血清型,以鼠伤寒沙门菌(38.24%,13/34)和肠炎沙门菌为主(20.59%,7/34);2014 — 2018年检出率高,为11.22%(261/2 307),菌型多,检出34种血清型,4,5,12:i:-沙门菌取代鼠伤寒沙门菌成为第1位常见血清型,鼠伤寒沙门菌居于第2位,之后是斯坦利沙门菌和肠炎沙门菌。
    结论余姚市沙门菌的优势菌主要以4,5,12:i:-沙门菌和鼠伤寒沙门菌为主,多重耐药严重,应进一步加强耐药监测。

     

    Abstract:
    ObjectiveTo investigate the infection status, serotype changes and drug sensitivity of Salmonella in patients with diarrhea in Yuyao of Zhejiang province and provide reference for prevention and clinical treatment.
    MethodsA total of 295 strains of Salmonella isolated from diarrhea patients from 2007 to 2018 were resuscitated, serotyped, and their drug susceptibilities were tested. The detection rates in different years were compared with χ2 test.
    ResultsThe detection rate of Salmonella was 8.60% in sentinel hospitals in Yuyao from 2007 to 2018, and the ratio of male to female was 1.07∶1. Salmonella could be detected in all age groups, mainly in children under 5 years old, the highest detection rate was in summer (10.20%) and the lowest in winter (1.64%). Thirty nine serotypes were detected, belonging to 10 serogroups, and the first four predominant serotypes were Salmonella 4,5,12:i:- (24.41%), S. typhimurium (15.25%), S. enteritidis (9.83%), and S. stanley (8.14%). The resistance rates of the 295 strains to penicillins, tetracyclines and sulfamethoxazole were high, but they were sensitive to other antibiotics, and the resistance rate to cephalosporins increased significantly during 2014–2018 compared with that during 2007–2013. A total of 107 strains (36.27%) were multi-drug resistant, belonging to predominant serotypes and accounting for 36.27%. In the past 12 years, the detection rate, serotypes and drug resistance of Salmonella changed. The detection rate was low during 2007–2013 (3.08%, 34/1 103), and 14 serotypes were detected, mainly S. typhimurium (38.24%, 13/34) and S. enteritis (20.59%, 7/34). The detection rate was high during 2014–2018 (11.22%, 261/2 307), and 34 serotypes were detected. Salmonella 4,5,12:i:- has replaced S. typhimurium as the first serotype, S. typhimurium ranked second, S. stanley and S. enteritidis ranked third.
    ConclusionThe predominant serotypes of Salmonella in Yuyao were mainly Salmonella 4,5,12:i:- and S. typhimurium. The surveillance of multi-drug resistance of Salmonella should be further strengthened.

     

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