郑文龙, 赵帅, 马洁, 罗莎, 纪艳, 江国虹. 2015-2016年天津市哨点医院腹泻病例诺如病毒感染状况调查[J]. 疾病监测, 2019, 34(1): 48-52. DOI: 10.3784/j.issn.1003-9961.2019.01.012
引用本文: 郑文龙, 赵帅, 马洁, 罗莎, 纪艳, 江国虹. 2015-2016年天津市哨点医院腹泻病例诺如病毒感染状况调查[J]. 疾病监测, 2019, 34(1): 48-52. DOI: 10.3784/j.issn.1003-9961.2019.01.012
Wenlong Zheng, Shuai Zhao, Jie Ma, Sha Luo, Yan Ji, Guohong Jiang. Investigation of noruvirus infection status in diarrhea cases in sentinel hospitals in Tianjin, 2015–2016[J]. Disease Surveillance, 2019, 34(1): 48-52. DOI: 10.3784/j.issn.1003-9961.2019.01.012
Citation: Wenlong Zheng, Shuai Zhao, Jie Ma, Sha Luo, Yan Ji, Guohong Jiang. Investigation of noruvirus infection status in diarrhea cases in sentinel hospitals in Tianjin, 2015–2016[J]. Disease Surveillance, 2019, 34(1): 48-52. DOI: 10.3784/j.issn.1003-9961.2019.01.012

2015-2016年天津市哨点医院腹泻病例诺如病毒感染状况调查

Investigation of noruvirus infection status in diarrhea cases in sentinel hospitals in Tianjin, 2015–2016

  • 摘要:
    目的 了解2015 — 2016年天津市腹泻散发病例中诺如病毒感染状况,为制定相关防治策略提供依据。
    方法 收集2015年1月至2016年12月天津市5家哨点医院上报的1 249例腹泻散发病例的流行病学资料,留存患者粪便样本,使用实时荧光定量反转录–聚合酶链式反应(RT-PCR)方法检测诺如病毒核酸,并对结果进行基因型别分析。
    结果 1 249例腹泻患者中诺如病毒检出率为14.41%(180/1 249);<1岁年龄组检出率最高,为26.07%(85/326),各年龄组检出率差异有统计学意义(P<0.01) ;一、四季度诺如病毒检出率明显高于二、三季度;滨海新区(30.00%)检出率高于城区(16.62%)和农村地区(11.89%);基因型以GⅡ型为主,GⅡ型单独感染占86.05%,GⅠ型单独感染占11.05%,GⅠ和GⅡ共同感染占2.91%。6 ~ 45岁GⅠ型所占比例较其他组高,最高达33.33%;GⅠ型主要分布在4 — 9月。
    结论 天津市哨点医院腹泻病例诺如病毒感染率较高,冬春季节高发,滨海新区是高发地区,婴幼儿为高发群体,优势基因型为GⅡ型,GⅠ型在中青年群体和夏季所占比例相对较高。 应根据诺如病毒流行特征开展防控工作,并针对重点人群进行主动监测。

     

    Abstract:
    Objective To understand the epidemiologic characteristics of norovirus infection in sporadic diarrhea cases in Tianjin during 2015–2016.
    Methods The epidemiological information of sporadic diarrhea cases were collected from five sentinel hospitals in Tianjin from January 2015 to December 2016. The stool samples were collected for norovirus nucleic acids detection by using real-time reverse transcription-PCR (real-time RT-PCR), and genotyping was performed for the detected strains.
    Results A total of 1 249 stool samples were collected from the diarrhea cases, the positive rate of norovirus was 14.41% (180/1 249); The highest detection rate was found in young children aged <1 year, with a detection rate of 26.07% (85/326); The differences in detection rate among different age groups had significance, (P<0.01). The detection rate of noroviruses was significantly higher in the first and fourth quarters than in the second and third quarters. The detection rates in Binhai new district, urban area and rural area were 30%, 16.62% and 11.89%, respectively. GⅡ was the predominant genotype of norovirus detected in the diarrhea cases. The infections with norovirus GⅡ accounted for 86.05%, the infection with norovirus GⅠ accounted for 11.05%, and co-infection with noroviruses GⅠ and GⅡ accounted for 2.91%. The infection rate of norovirus GⅠwas highest in age group 6–45 years (33.33%). The infections with norovirus CⅠ mainly occurred during April-September.
    Conclusion The infection rate of norovirus in diarrhea cases in Tianjin sentinel hospital was high. The incidence in winter and spring was high. Binhai new district was an area with high incidence, infants and young children were group with high incidence. GⅡ was the predominant genotype. The incidence of infection with norovirus GⅠ was relatively high in young and middle-aged groups. It is necessary to conduct the prevention and control of norovirus infection according to the epidemic characteristics, and active surveillance should be conducted in populations at high risk.

     

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