Abstract:
Objective To investigate the distribution and drug susceptibility of pathogens causing bloodstream infection isolated from blood samples of cancer patients in Sichuan Cancer Hospital from January 2012 to December 2016 and provide evidence for the rational use of antibiotics.
Methods The drug susceptibility of the pathogen strains isolated from the cancer patients were analyzed with software WHONET 5.6 according to the breakpoints of Clinical and Laboratory Standards Institute in 2016.
Results A total of 603 pathogen strains were isolated from blood samples of the cancer patients, including 165 gram positive cocci strains, 434 gram negative bacilli strains and 4 fungi strains, respectively. In the all cancer patients, the pathogen isolation rate was highest in cervical carcinoma patients, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, coagulase negative Staphylococcus and Enterobacter cloacae were the most common pathogens isolated, accounting for 34.33%, 13.27%, 9.29%, 6.80% and 4.98%, respectively. Methicillin resistant strains accounted for 12.50% and 73.17%, respectively, in S. aureus and coagulase negative Staphylococcus isolates. The strains of Enterobacteriaceae were still highly sensitive to carbapenems, less than 5.00% of these strains were resistant to carbapenems. In contrast, Acinetobacter baumannii was highly resistant to carbapenems, and about 80.00% of A. baumannii strains were resistant to imipenem and meropenem, respectively.
Conclusion Enterobacteriaceae was the main pathogens isolated from the blood samples of the cancer patients. Their drug susceptibilities varied. The resistance of A. baumannii to carbapenem was serious. Therefore, it is necessary to use antibiotics rationally according to the type of cancer and related drug susceptibility test results.