龙奇志, 贾华云, 何礼, 王岚, 胡世雄, 高立冬, 李俊华. 2016-2018年湖南省株洲市弯曲菌的流行特征及耐药性分析[J]. 疾病监测, 2020, 35(1): 34-38. DOI: 10.3784/j.issn.1003-9961.2020.01.009
引用本文: 龙奇志, 贾华云, 何礼, 王岚, 胡世雄, 高立冬, 李俊华. 2016-2018年湖南省株洲市弯曲菌的流行特征及耐药性分析[J]. 疾病监测, 2020, 35(1): 34-38. DOI: 10.3784/j.issn.1003-9961.2020.01.009
Qizhi Long, Huayun Jia, Li He, Lan Wang, Shixiong Hu, Lidong Gao, Junhua Li. Epidemiologic characteristics and drug resistance of Campylobacter in Zhuzhou, Hunan, 2016–2018[J]. Disease Surveillance, 2020, 35(1): 34-38. DOI: 10.3784/j.issn.1003-9961.2020.01.009
Citation: Qizhi Long, Huayun Jia, Li He, Lan Wang, Shixiong Hu, Lidong Gao, Junhua Li. Epidemiologic characteristics and drug resistance of Campylobacter in Zhuzhou, Hunan, 2016–2018[J]. Disease Surveillance, 2020, 35(1): 34-38. DOI: 10.3784/j.issn.1003-9961.2020.01.009

2016-2018年湖南省株洲市弯曲菌的流行特征及耐药性分析

Epidemiologic characteristics and drug resistance of Campylobacter in Zhuzhou, Hunan, 2016–2018

  • 摘要:
    目的了解湖南省株洲市弯曲菌的流行病学现状和耐药特征。
    方法2016年7月至2018年6月,在株洲市对腹泻病例和无腹泻症状儿童开展流行病学调查,并采集粪便标本进行弯曲菌的分离培养和耐药性分析。
    结果共调查人群粪便标本450份,弯曲菌的检出率为6.44%(29/450),其中无腹泻症状儿童的检出率为1.00%(1/100),腹泻病例的检出率为8.00%(28/350)。 弯曲菌感染的临床症状以腹泻、腹痛、黏液便、粪便镜检均有红、白细胞为主;5~岁组检出率较高,为19.44%(7/36);学生的检出率最高,为17.65%(6/34);男、女性患者的检出率差异无统计学意义(χ2=1.354,P=0.245);春秋季弯曲菌的检出率高于夏冬季。 29株弯曲菌中24株为空肠弯曲菌,5株为结肠弯曲菌,其中41.38%的菌株为多重耐药菌株,菌株对萘啶酸、环丙沙星和四环素的耐药性较强,分别为96.15%、88.46%、76.92%。
    结论空肠弯曲菌、结肠弯曲菌感染已成为株洲市感染性腹泻的重要病原菌之一,耐药性严重并存在多重耐药现象,应加强弯曲菌的监测和防控。

     

    Abstract:
    ObjectiveTo understand the epidemiologic characteristics and drug resistance of Campylobacter in Zhuzhou of Hunan province.
    MethodsEpidemiologic investigation was conducted in diarrhea cases and children without diarrhea in Zhuzhou from July 2016 to June 2018, and their stool samples were collected. The stool samples were used for the isolation of Campylobacter. The isolated Campylobacter strains were tested for drug susceptibility.
    ResultsA total of 450 cases were surveyed. The detection rate of Campylobacter was 6.44% (29/450). The detection rate in children without diarrhea was 1.00% (1/100), and the detection rate in diarrhea cases was 8.00% (28/350). The clinical symptoms of Campylobacter infection were diarrhea, abdominal pain, mucus stool, and the stool microscopic examination results were mainly characterized by the detections of erythrocyte and leukocyte. The detection rate in age group 5– years was 19.44% (7/36). The infection cases were mainly students 17.65% (6/34). There was no significant difference in the detection rate between man and woman (χ2=1.354, P=0.245). The detection rate of Campylobacter was higher in spring and autumn than in summer and winter. In the 29 strains, 24 were Campylobacter jejuni and 5 were C. colon. In the 29 strains, 41.38% were multidrug resistant. The resistant rates to nalidixic acid, ciprofloxacin, tetracyvline were 96.15%, 88.46% and 76.92%, respectively.
    ConclusionCampylobacter has become one of the important pathogens causing diarrhea in Zhuzhou, and it showed serious drug resistance and multi-drug resistance, to which the monitoring and control measures should be strengthened.

     

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