石向辉, 范苏云, 朱纯青, 钟剑明, 曾宇苑, 申红卫. 深圳市一起B群流行性脑脊髓膜炎疫情的调查[J]. 疾病监测, 2019, 34(1): 80-83. DOI: 10.3784/j.issn.1003-9961.2019.01.019
引用本文: 石向辉, 范苏云, 朱纯青, 钟剑明, 曾宇苑, 申红卫. 深圳市一起B群流行性脑脊髓膜炎疫情的调查[J]. 疾病监测, 2019, 34(1): 80-83. DOI: 10.3784/j.issn.1003-9961.2019.01.019
Xianghui Shi, Suyun Fan, Chunqing Zhu, Jianming Zhong, Yuyuan Zeng, Hongwei Shen. Investigation of a serogroup B meningococcal meningitis case in Shenzhen[J]. Disease Surveillance, 2019, 34(1): 80-83. DOI: 10.3784/j.issn.1003-9961.2019.01.019
Citation: Xianghui Shi, Suyun Fan, Chunqing Zhu, Jianming Zhong, Yuyuan Zeng, Hongwei Shen. Investigation of a serogroup B meningococcal meningitis case in Shenzhen[J]. Disease Surveillance, 2019, 34(1): 80-83. DOI: 10.3784/j.issn.1003-9961.2019.01.019

深圳市一起B群流行性脑脊髓膜炎疫情的调查

Investigation of a serogroup B meningococcal meningitis case in Shenzhen

  • 摘要:
    目的 调查B群流行性脑脊髓膜炎(流脑)疫情的原因。
    方法 于2018年2月22、27日对患者和密切接触者进行流行病学调查,并收集脑脊液、血液和咽拭子样品进行分离培养、PCR检测和二代测序。
    结果 在患者血液及其母亲咽拭子中均分离出B群脑膜炎奈瑟菌,多位点序列分型均为ST-3200/CC4821,2株菌的16S rRNA及耐药基因、多肽编码基因的相似性为100%。
    结论 该疫情是由健康携带B群脑膜炎奈瑟菌的母亲传播给患者而引起。

     

    Abstract:
    Objective To investigate the cause of a serogroup B meningococcal meningitis case in Shenzhen.
    Methods The epidemiological investigation was conducted for the case and close contacts. The cerebrospinal fluid and blood samples from the case and the throat swabs from the contacts were collected for the pathogen isolation/culture and PCR detection. The isolates were sequenced with next generation sequencing method.
    Results Two strains of serogroup B Neisseria meningitidis were isolated from the blood sample of the case and throat swab of case’s mother, respectively. The two isolates shared the same multilocus sequence typing(MLST) type of ST-3200/CC4821, same 16S rRNA sequence, and same alleles of genes related to antibiotic susceptibility and coding peptides.
    Conclusion The meningococcal disease case was caused by the transmission of serogroup B N. meningitidis from case’ mother who was a healthy carrier.

     

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