Objective  To analyze the seasonal characteristics of hand foot and mouth disease (HFMD) in Yuyao of Zhejiang province from 2012 to 2021 and provide evidence for the prevention, control and early warning of HFMD and development of HFMD immunization strategy in Yuyao.

  Methods  The information of HFMD cases in Yuyao from 2012 to 2021 were collected China Disease Control and Prevention Information System for an analysis on seasonal distribution of HFMD in Yuyao by concentration and circular distribution methods.

  Results  The average annual incidence rate of HFMD in Yuyao was 312.95/100 000, and the incidence was high every other year. The incidence rate in men (363.63/100 000) was higher than that in women (260.65/100 000). The cases were mainly distributed in children outside child care settings, accounting for 63.90%. The incidence of HFMD had seasonality (M=0.3031), the annual incidence was high from March 16 to September 11 ( \overline \alpha =162.33°, S=88.53°, Z=3113.58, P＜0.05) and peaked on June 14.

  Conclusion  The incidence rate of HFMD in Yuyao is higher compared with some areas in China. The prevention and control of HFMD is a challenge. The incidence of HFMD has seasonality. It is necessary to be prepared for the comprehensive prevention and control of HFMD before the peak period to effectively reduce the incidence of the disease.