Abstract: In November 2021, a total of 65 infectious diseases were reported globally, affecting 226 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were Corona virus disease 2019 (COVID-19, 226), dengue fever (31), measles (21), poliomyelitis (11) and cholera (10). The top five infectious diseases with highest case fatality rates were Ebola virus disease (81.8%), Lassa fever (18.6%), yellow fever (15.3%), meningitis (7.9%) and plague (7.6%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, cholera, dengue fever and yellow fever. The prevalent infectious diseases in Asia were COVID-19 and dengue fever, the prevalent infectious diseases in Africa were COVID-19, Ebola virus disease, cholera, yellow fever, Lassa fever, poliomyelitis, malaria and measles, the prevalent infectious diseases in America were COVID-19, dengue fever, chikungunya fever and Zika virus disease, the prevalent infectious disease in Europe were COVID-19 and West Nile fever.