孙永德, 孟宗达, 孙德贵, 唐景裕, 刘彩云. 输血后丙型肝炎前瞻性调查[J]. 疾病监测, 1995, 10(8): 234-238. DOI: 10.3784/j.issn.1003-9961.1995.8.234
引用本文: 孙永德, 孟宗达, 孙德贵, 唐景裕, 刘彩云. 输血后丙型肝炎前瞻性调查[J]. 疾病监测, 1995, 10(8): 234-238. DOI: 10.3784/j.issn.1003-9961.1995.8.234
Sun Yongde et al, . A Prospective Study on Posttransfusion Hepatitis Type C[J]. Disease Surveillance, 1995, 10(8): 234-238. DOI: 10.3784/j.issn.1003-9961.1995.8.234
Citation: Sun Yongde et al, . A Prospective Study on Posttransfusion Hepatitis Type C[J]. Disease Surveillance, 1995, 10(8): 234-238. DOI: 10.3784/j.issn.1003-9961.1995.8.234

输血后丙型肝炎前瞻性调查

A Prospective Study on Posttransfusion Hepatitis Type C

  • 摘要: 1990-1991年在河北省甲乙两县用前瞻性方法调查了输血后肝炎、甲县献血员在献血前筛查ALT和HBsAg,观察了64名受血者;乙县献血员献血前不筛查任何指标,观察了90名受血者。结果输血后肝炎发生率,甲县为21.9%,乙县为44.4%;输血后抗-HCV阳转率分别为18.8%和45.6%;其中输血后丙型肝炎分别为14.1%和41.1%。ALT首次异常距输血平均时间,甲县为51.9±20。9天,乙县为48.2±16.8天,抗-HCV阳性受血者为35.9±17.9天。抗-HCV阳转距输血平均时间,甲县42.4±15.9天,乙县38.4±11.8天。输入抗,HCV阳性或阴性血的受血者,HCV总感染率分别为88.2%(45/51)和7.8%(8/103),其中输血后丙型肝炎发生率分别为78.4%(40/51)和5.8%(6/103)。既往HCV隐性感染者输血后丙型肝炎发生率为52.4%(11/21)。

     

    Abstract: A prospective study on posttransfusion hepatitic type C(PT-HC) was carried out during 1990 to 1991 in county A and B of hebei Province. In county A, the blood donors were screened using ALT and HBsAg before blood donation, and 64 recipients were followedup; in county B, the blood donors were not screened using any marker before donation, and 90 recitients were followedup. The total iufectious rates of posttransfusion hepatitis were 21.9% and 44.4% in county A and B respectively. The seroconversion rates of anti-HCV were 18.8% and 45.6% in county Aand B,and the attack rates of PT-HC were 14.4% and 41.1%,respectively.The time of first detected ALT elevation to blood transfusion were 51.9±20.9%days and 48.2±16.8 days in county A and B respectively,and 35.9±17.9 for patients who were positive of anti-HCV before blood transfusion.The average time of positive Conversion of anti-HCV to blood transfusion was 42.4±15.9 days in county A,38.4±11.8 days in county B.The infection rates of HCV were 88.2%(45/51)and 7.8%(8/103) for patients who were transfused blood with and aithout anti-HCV respectively,and among them the attack rates of PT-HC were 78.4%(40/51) and 5.8% (6/103).The attack rate of PT-HC for cases who had been infected with HCV subclinically before blood transfusion was 52.4%(11/21).

     

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