Abstract: In this study,the serun values of carbohydrate antigen(CA19-9 CA50),serum ferritin(SF) and carcinoembryonic antigen (CEA)were measured in 21 patients with pancreatic carcinoma(PC) and 56 patients with benign diseases of digestive system.Serum concentrations of various markers and positive rate in Patients were significantly higher than those in the control group,the value between patients and controls was statistically different(P0.01).The sensitivity of CA19-9 was the highest 76.19%,the second was CA50 and both showed high specificity and diagnostic accuracy.The positive rate of combination of CA19-9 and CA50 was 85.71%,but did not exceed that of each marker test alone.The cambined use of these four cuncer markers elevated sensitivity to 100%,which remarkably discriminated with each test used alone,whereas specificity decreased.So it was concluded that CA19-9 and CA50 could serve as valuble indicaters in the diagnosis of PC.The combined assay of CA19-9+CA50 or SF+CEA could enhance the sensitivity in diagnosis of malignant pacreatic diseases also was of sufficient value for screening patients with a suspicion to have pancreatic cancer.