专题协作组. 中国肾综合征出血热疫苗近期防病效果[J]. 疾病监测, 1996, 11(3): 85-88. DOI: 10.3784/j.issn.1003-9961.1996.3.85
引用本文: 专题协作组. 中国肾综合征出血热疫苗近期防病效果[J]. 疾病监测, 1996, 11(3): 85-88. DOI: 10.3784/j.issn.1003-9961.1996.3.85
chen Huangxin et al. A Comparative Study on the short-term Preventive Effect of Hemorrhagic Fever with Renal Syndrom(HFRS)Vaceine in China[J]. Disease Surveillance, 1996, 11(3): 85-88. DOI: 10.3784/j.issn.1003-9961.1996.3.85
Citation: chen Huangxin et al. A Comparative Study on the short-term Preventive Effect of Hemorrhagic Fever with Renal Syndrom(HFRS)Vaceine in China[J]. Disease Surveillance, 1996, 11(3): 85-88. DOI: 10.3784/j.issn.1003-9961.1996.3.85

中国肾综合征出血热疫苗近期防病效果

A Comparative Study on the short-term Preventive Effect of Hemorrhagic Fever with Renal Syndrom(HFRS)Vaceine in China

  • 摘要: 对中国试生产的肾综合征出血热沙鼠肾细胞Ⅰ型灭活疫苗(上海生研所和天元公司)、乳鼠脑纯化Ⅰ型灭活疫苗(兰州生研所)和地鼠肾细胞Ⅰ型灭活疫苗(长春生研所),在疫区进行了人群接种,并对其安全性、血清学和近期防病效果进行了考核。结果表明,三种疫苗安全性皆较好,上海沙鼠苗、天元沙鼠苗、鼠脑苗和地鼠苗中强反应率分别为0.56%、0.03%、3.26%和1.57%。三种疫苗三针全程免疫后14天,其中和抗体阳转率地鼠苗79.04%、上海沙鼠苗58.33%、天元沙鼠苗70.00%、鼠脑苗50.00%;荧光抗体阳转率地鼠苗65.57%、上海沙鼠苗93.69%、天元沙鼠苗83.33%、鼠脑苗83.53%。三种疫苗近期防病诳果均较好,其保护率:地鼠苗79.19%、上达沙鼠苗95.81%、天元沙鼠苗96.60%%、鼠脑苗95.39%。

     

    Abstract: A comparative study on the safety,serological and short-term epidemiologiqal ef-fects of HFRS vaccines including inactivated Mongolial Gerbals Kidney Cell Type I vaccine(pro-duced by Shanghai Institute of Biological Product and Tianyuan Company),inactiveted purified suckling mouse brain Type I vaccine(produced by Lanzhou InstRute of Biological Products and Inactivated Hamster kidney Cell Type I vaccine(produced by Changchun Institute of Biological products)was carried out in the residents of infectious loci of HFRS.The results indicated that all of these 3 vaccines had good safety.the post vaccination reactions of these vaecines were 0.03~0.56%,3.26%and 1.57 resectively.The serum conversion rates ofneutralizing antiodies against HFRS after 14 days mmunization of the above vaccines were 58.33%~70.0%,50% and 79.04%respectively.The conversion rates of Immunofluoresccne Antibody of above vaccines were 83.33%~93.69%,83.53%and 65.57%respectively.The short-term preventive effects of all the above 3 vaccines were 95.81%~96.60%,95.39%and 97.19%respetively。

     

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