Abstract: The study on prevention of children′s diarrheal diseases and improvement of case management in Hunan province from 1991 to 1995 was carried out.After taking comprehensive measures such as training,sanitation publicity,promotion of breast feeding,improvement of water supplies,improvement of the diagnosis and treatment of diarrheal diseases,the diarrhoea incidence of children under 5 years was decreased by 2.3 times /child/year.The use rate of ORS was risen up from 9.89% to 37.38%. Among the children taken medicine,the use rate of antibiotics was dropped from 75.41% to 57.65%. The rate of caretakers having correct knowledge of referral was increased from 16.11% to 73.79%. Feeding behavior of caretakers was improved. The results indicated that comprehensive mesures was very effective for redusing the incidence of children's diarrheal disease and improving case management.