布鲁氏菌蛋白变应原的应用研究

A Study on the Application of Allergen of Brucella Protein

摘要: 用纯化的布氏菌蛋白变应原（Ｂｒ-ＰＡ），对布病病人、布氏菌隐性感染者、布氏菌苗免疫者、肺结核和其他病人及健康人群做皮内变态反应试验。结果显示，其显著特点是安全性好，无副作用，非特异性反应低于现行国产市售菌素（表现在速发反应少，反应面积小）；在保证该变应原具有良好的特异性和敏感性的前提下，提出了其阳性判定标准。表明，该蛋白变应原为纯度高、质量好、易标化的新型布鲁氏菌病皮内诊断制剂

Abstract: Intradermal allergic reaction was carried out in brucellosis patients,latent infections of brucella,immunized persons by brucella vaccine,tuberculosis, other patients and healthy people by using purified brucella protein allergen (BrPA).The data indicated that it was safe,no side reaction and the nonspecific reaction was lower than the present brucellin which was widely used in China currently.A positive reaction criterion was suggested as well.The results showed that this highly purified protein allergen was easy to standalize and also revealed that it was a new preparation and can instead of the current brucellin for diagnosis of brucellosis.