广州市吸毒人群乙型肝炎病毒感染状况及感染模式调查

李美霞; 徐慧芳; 王晓艳; 曹毅敏; 周秀珍; 黄源华

doi:10.3784/j.issn.1003-9961.1999.10.368

广州市吸毒人群乙型肝炎病毒感染状况及感染模式调查

Study on HBV Infection and Infection Modes in Drug Users in Guangzhou

Li Meixia. et al,

摘要

摘要: 为了解广州市吸毒人群乙型肝炎病毒（ＨＢＶ）感染情况，用ＥＬＩＡＳＡ法对１９９５～１９９８年在广州市某戒毒所戒毒的１６６３人毒瘾者进行ＨＢＶ感染标志物检测。结果吸毒人群ＨＢｓＡｇ携带率为１９．９％，ＨＢＶ总感染率为８６．１％。静脉注射毒瘾者ＨＢｓＡｇ阳性率（２２．８％）明显高于口吸（追龙）毒瘾者（１２．３％），差异有统计学意义（Ｐ＜０．０１）；男性毒瘾者ＨＢｓＡｇ携带率（２１．２％）高于女性（１４．１％），二者差异有显著性。调查发现１４３２例ＨＢＶ感染的吸毒人群乙型肝炎病毒的感染模式有２１种，其中以ＨＢｓＡｂ、ＨＢｃＡｂ、ＨＢｓＡｂ、ＨＢｃＡｂ、ＨＢｓＡｇ、ＨＢｅＡｂ、ＨＢｃＡｂ、ＨＢｓＡｇ、ＨＢｅＡｇ、ＨＢｃＡｂ及ＨＢｓＡｇ、ＨＢｅＡｇ为多见，阳性构成分别为２８．５６％、２０．３９％、１６．４１％、８．５９％、６．４９％、和６．２０％。应采取加强吸毒人群防病知识宣传，同时实施乙肝疫苗免疫的综合性防制措施，以控制该人群乙型肝炎的传播和流行。

Abstract: The aim of this study was to describe the situation of hepatitis B virus(HBV)infection in drug users in Guangzhou. 1663 drug users who received treatment in a detoxification institute in Guangzhou during 1995 to 1998 were describe for HBV markers by ELIASA. The result showed that HBsAg carrying rate was 19.9% and higher in intravenous drug users (22.8%) than that in oral drug users (12.3%) also was higher in male drug users (21.2%) than in female drug users (14.4%), both had statistical significance. There were 21 infection modes in the 1432 HBV positive drug users, of which HBsAb·HBcAb,HBcAb,HBsAg·HBeAb·HBsAg·HBeAg·HBcAb and HBsAg were common.Their consititution rate were 28.56%,20.39%,16.41%,8.59%,6.49%,and 6.20% respectively.Combination strategies of health education and vaccination were recommended in order to control HBV transmission in drug users.

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