1997年中国部分省狂犬病疫情回升与疫苗质量下降关系

吴泰才; 葛宪民; 王学燕; 黄德惠

doi:10.3784/j.issn.1003-9961.1999.9.327

1997年中国部分省狂犬病疫情回升与疫苗质量下降关系

The Relationship between the Reincreasing Rate of Rabies and the Quality of Vaccine in Some Provinces in China 1997

Wu Taicai. et al,

摘要

摘要: 本文报导了１９９７年中国部分省区狂犬病疫情回升情况，全回升率３９.６％（２２２／１５９），其中以江西、江苏和广西三省区较高，分别为２８５.７％（２７／７）、１０９.１％（２３／１１）、１０８.３％（５０／２４）。其原因近年疫苗生产受到市场经济冲击，疫苗质量不稳定。如全程接种后抗体逐年下降，其阳性率由１９９４年９１ ３％（５４３／５９５）下降至１９９８年６８.０％（２９５／４３２）下降了２３.０％。在同一疫苗来源时，接种２针与３针，抗体阳转率１９９６年比１９９４年分别下降了１８.０％与４６.０％，具有显著性意义，χ２＝５．５５，Ｐ＜００５。也出现了２例无效病例。国家１９９６年抽检结果也证实，作者对１９９８年后全国疫情作了预测。

Abstract: The morbidity of rabies was increased again in some provinces of China 1997. The re-increasing rate was 39.6%(222/159) but it was very apparent in Jiangxi (285.7%, 27/7), Jiangsu (109.1%,23/11) and Guangxi (108.3%, 50/24). The cause may be related to the quality of vaccine. For instance, the antibody titer of post-vaccination was decreased yearly. The positive converse rate was decreased from 91.3%(543/595) in 1994 to 68% (295/432) in 1998. Even using the vaccine made by the same factory, the positive converse rates after 2nd and 3rd vaccination in 1996 were decreased by 18% and 46% in comparison with 1994(p<0.05).Furthermore two cases without any effect were reported.National control center showed a similar tendency.The expected morbidity of rabies in 1998 in China was forecased.

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