Abstract: Objective:To explore prevalence of hepatitis G virus(HGV) & transfusion transmitted virus(TTV) infection and their risk factors among the general population in Shenzhen Methods: According to the cluster sampling,1843 subjects were selected randomly and tested for anti-HGV by ELISA;and the positive samples were further tested for HGV RNA using RT-PCR; and tested for TTV DNA by Npcr. Results: The prevalence rate of HGV RNAwas2.33%(2.45%for male and 2.20%for female,respectively);and the prevalence rate of TTV DNA was 14.77%(17.86% for male and 12.0% for female,respectively).There was no significant dufference between males and females,nor with different age groups.The histories of hepatitis,surgical dental operations were not associated with HGV and TTV infection.Hepatitis B vaccination and positivity of HBsAg,anti-HBs and anti-HBc antibodies were not related to HGV RNA and TTV DNA prevalence rate.However,HGV RNA prevalence rate was higher in middle school students and teachers than other professional groups;and TTV DNA prevalence rate was higher in tax collectors and teachers than others.Conclusion:The prevalence rates of HGV RNA and TTV DNA seemed to be high among the general population in shenzhen,but the risk factors of HGV and TTV infecton in the population need to be further studied.