急性弛缓性麻痹病例中不同病毒感染病例的流行病学和临床特征

张振国; 宋会军; 张晓哗; 离彧; 陈玫; 张玉琦; 孙印旗

doi:10.3784/j.issn.1003-9961.2000.2.45

急性弛缓性麻痹病例中不同病毒感染病例的流行病学和临床特征

Epidemiological and Clinical Characteristics of Acute Flaccid Paralysis Patients infected with Vaccine Poliovirus or Non-polio Enterovirus

Zhang Zhenguo. et al,

摘要

摘要: 本研究报告了河北省 1996～ 1998年AFP病例中脊髓灰质炎疫苗病毒、非脊髓灰质炎肠道病毒 (NPEV)感染的流行病学和临床特征 ,显示NPEV感染有明显的夏秋季感染高峰 ,感染主要发生在小年龄组人群 :AFP病例中NPEV感染者作为一组病例 ,一般不会与脊灰诊断相混淆 ,在有明确诊断的病例中以格林巴利综合征为最多 ,但资料同时也显示有 38%的NPEV感染者有与脊灰相类似的麻痹时发热和急速进行性麻痹的临床表现 ,5 %的NPEV感染者除上述症状外 ,还在发病后60天残留麻痹。分离到脊髓灰质炎疫苗病毒的病例 ,更具有与野病毒感染相似的临床表现 ,麻痹后恢复慢 ,有较高的麻痹残留率 ,达 20.9% ,但无明显的季节性分布。

Abstract: The season peak of AFP patients infected with vaccine poliovirus or non-polio enterovirus is in summer and autume every year. And the highest infectious rate is in little age group. This report demonstrates that isolation of NPEV from AFP cases is common in Hebei Province. Over the period 1996-1998, 66.66% of all viral isolates from AFP cases were NPEV. The data suggest that AFP cases with NPEV isolates are generally unlikely to be confused with poliomyelitis. However the data also indicate that the NPEV group are not homogeneous,up to 38% mimick poliomyelitis chinically by exhibiting fever at onset of paralysis and rapid progression of paralysis,and 5% of them have not recovered.

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