Abstract: Purpose: To study the epidemic characteristics and types of foci and preventive strategy of HFRS. Method: FAT was used to detected HV antigen in lungs of mouse, and IFAT for antibody detection in HFRS patients. HI was used to determine the serological type. Result: All 2 230 cases of whole province were mainly distributed in east and west hill areas of Zhejiang province. January and May to July were the two peak periods of HFRS in Zhejinag. Most of the cases were young strong peasants. Conclusion: Apodemus agrarius was the main mouse in mixed type areas,we should select bivalent vaccine for controlling this disease.