徐州地区TTV感染的流行病学研究
Epidemiological Study of TTV Infection in Xuzhou Region
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摘要: 为了探讨徐州地区正常人群中输血传播病毒 (TTV)感染情况及其流行病学特征。用随机整群及分层随机法抽取研究对象 ,在国内首次采用酶联免疫吸附试验 (ELISA)法检测该人群血清中TTVIgG抗体。结果表明 ,对 1268名不同年龄的正常人群调查表明 ,徐州地区正常人群中TTVIgG的总阳性率为 5.36 % ,男女性阳性率分别为 3.81%和 6.67% ,女性略高于男性。年龄、职业、城乡之间TTVIgG阳性率差异无显著性意义。但有手术史和输血史者中TTVIgG阳性率最高 ,分别为 27.27%和 11.48% ,显著高于其它因素者。结果表明 ,徐州地区正常人中TTV感染率与HBV感染率基本相同 ,有手术史和输血史者TTV感染率较高 ,进一步证实血液是TTV传播的重要因素之一 ,同时也提示TTV可能与HBV感染相类似 ,存在“健康携带状态”。Abstract: ObjectiveToexploretheprevalenceoftransfusiontransmittedvirus(TTV)infectionanditsepidemio logicalfeaturesamongnormalpopulationinXuzhouregion .MethodsBasedontheclusterrandomandmulti -stage sampling ,enzymelinkedimmunosorbentassay (ELISA)wasusedtodeterminetheserumanti-TTVamongnormal population .ResultsThetotalpositiverateofTTVIgGwas 5.36%among 1 2 68normalsubjectsinXuzhouregion . 3.81 %formaleand 6 67%forfemalerespectively,ruralfemaleishigherthanmale Therewasnosignificantdiffer encebetweenagegroups、professions、urban and population,but the positive rate in people who has the histories of operations and transfusions. The results confirmed that TTV might be transmitted by blood transfusion and suggeted that TTV might exist in "health carrier"status.
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