Abstract: Purpose: To study the epidemiological characteristics and make the preventive strategy of HFRS. Method: FAT was used to detected HV antigen in lungs of mouse, and IFAT for antibody detection in HFRS patients. Result: All 1507 cases in whole province were mainly distributed in east west and south hill areas of Zhejiang province. May, June and December were the two peak periods of HFRS in Zhejiang. Most of the cases were young strong peasants. Conclusion: Apodemus agrarius was the main kind of mouse in mixed type areas,we should select bivalent vaccine for decreasing the incidence rate of HFRS.