Abstract: Objective To study the incidence of sexual transmitted diseases in commerical female sex workers (CFSW) in china and to estimate the effects of intervention measures. Metheds Periodical survey?STD diagnosis and treatment?condom using and other intervention measures were conducted in commercial sex workers both in downtown and in the female Education Bureaus. The two groups were monitored and compared with each other. Results After comprehensive intervention strategy, the incidence of STD were decreased.For Syphilis,Comparing with themselves in Sept. 1999 and Sept. 2001,the intervention group were with significant difference (P0.05).Conclusion The comprehensive intervention strategy to the commercial female sex workers was of benefit to the control of STD.