支原体与早产、新生儿肺炎关系研究
Study on The Relations between Premature、 Pneumonic Neonate and Mycoplasma Infection
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摘要: 目的:了解解脲脲原体（Uu）、肺炎支原体（Wpn）、人型支原体（Mh）、生殖支原体（Mg）、发酵支原体（Mf）5种支原体感染与早产、新生儿肺炎的关系。方法:收集151例正常新生儿（剖宫产98例）、105例早产儿（剖宫产50例）和71例新生儿肺炎者（剖宫产48例）出生24小时内的咽拭子标本,应用套式聚合酶链式反应（nestedPolymerase Chain Reaction, nPCR）技术检测5种支原体的特异性核酸。结果:正常新生儿检出Un、Mpn和Mh3种支原体,阳性率分别为8.6％、3.3％和2.0％;早产儿检出Uu、Mpn、Mh和Mg4种支原体,阳性率分别为44.8％、21.9％、10.5％和4.8％,均明显高于正常新生儿（P均3）;新生儿肺炎者检出Uu、Mpn、Mh和Mg4种支原体,其中Uu、Mpn分别为42.3％、25.4％明显高于正常新生儿（P均3）。剖宫产出的早产儿和新生儿肺炎者支原体检出率分别为74.0％和56.3％,明显高于正常新生儿的10.2％（P均3）。结论:Uu、Mpn、Mh和Mg等围产期感染可致早产和新生儿肺炎。Abstract: To explore the relations between the premature 、 pneumonic neonate and the infections of Ureaplas-ma urealyticum (Uu)、 Mycoplasma pneumoniae ( Mpn)、 M. hominis ( Mh)、M. genitalium ( Mg) and M. fermentans (Mf) . The specimens of the throat swab were obtained in 151 health neonate 、 105 premature and 71 pneumonic neo-nate. These specimens were detected by nested polymerase chain reaction. The results showed that the positive rates of Uu、Mpn and Mh in health neonate were 8.6% 、3.3% and 2.0% ; those of Uu、Mpn、Mh and Mg in premature were 44.8%、21.9%、10.% and 4.8% (P all 3.0);those of Uu and Mpn in pneumonic neonate were 42.3% and 25.4% (P all3.0).These results indicated that mycoplasma infection might be the important cause of the premature、pneumonic neonate.
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