Abstract: Objective To learn the clinical distribution of hospital infection caused by enterococcus and drug-tolerance of enterococcus to commo Method National clinical operation rules and sensititre Aris toi- dentify enterococcus separated from clinical specimen paper distribution drug sensitive test andβ- lactamase test,and using WHONET software to analyze data.Results The feces enterococcus wsa 91.2% in 137 strains of enterococcus,and the enterococcus was 7.3%;enterococcus producing β-lactamase was 6.6%;the rate of drug-tolerance to vancomycin was 2.9%;the rate of drug-tolerance to high chroma gentamicin was 76.6%. The rate of enterococcus in urine spcimen was the highest among all kinds of infec-tion specimen,(42.3%). Conclusions Enterococcus was one of main bacteria that caused hospital infec-tion,and feces enterococcus was the primary. The infection of urinary system and respiratory system was pri-mary and the drug-tolerance of enterococcus was severe. We should use varied therapy project to cure differ-ent enterococcus infection.