杨莉, 王玲, 周曾全, 闫文云, 张光彩, 王玉, 崔文庆, 陆继云, 李江嵘, 施玉华. 325例HIV/AIDS免疫功能状况及其与病程关系的研究[J]. 疾病监测, 2004, 19(6): 205-211. DOI: 10.3784/j.issn.1003-9961.2004.6.205
引用本文: 杨莉, 王玲, 周曾全, 闫文云, 张光彩, 王玉, 崔文庆, 陆继云, 李江嵘, 施玉华. 325例HIV/AIDS免疫功能状况及其与病程关系的研究[J]. 疾病监测, 2004, 19(6): 205-211. DOI: 10.3784/j.issn.1003-9961.2004.6.205
YANG li. et al, . Study on Relationship Between Immunity Function and Courses of Disease for 325 Cases of HIV/AIDS[J]. Disease Surveillance, 2004, 19(6): 205-211. DOI: 10.3784/j.issn.1003-9961.2004.6.205
Citation: YANG li. et al, . Study on Relationship Between Immunity Function and Courses of Disease for 325 Cases of HIV/AIDS[J]. Disease Surveillance, 2004, 19(6): 205-211. DOI: 10.3784/j.issn.1003-9961.2004.6.205

325例HIV/AIDS免疫功能状况及其与病程关系的研究

Study on Relationship Between Immunity Function and Courses of Disease for 325 Cases of HIV/AIDS

  • 摘要: 目的 了解云南HIV感染者/AIDS病人的免疫功能状况及其与病程的关系,探索适合云南省省情的HIV/AIDS治疗的实验室指标。方法 收集门诊325例HIV/AIDS的相关流行病学资料和静脉血,应用流式细胞计数仪和三标TruCount荧光标记单克隆抗体试剂盒进行CD4、CD8的绝对计数,使用b-DNA仪和RNA3.0 Assay版本试剂对其中151例进行病毒载量的测定。结果 (1)165例HIV感染者和160例艾滋病病人的CD4、CD4/CD8均未表现出性别差异(P>0.05)。(2)HIV感染者和AIDS病人CD4、CD8和CD4/CD8未表现出年龄差异(P>0.05)。(3)HIV感染者和AIDS病人CD4、CD8和CD4/CD8汉族与傣族无差异(P>0.05)。(4)AIDS病人的CD4细胞明显低于HIV感染者,且均低于正常对照组,三者之间差异有显著性(P4细胞数不同,将研究对象分为3组:A组CD4细胞>350/μl,B组CD4细胞为350-200/μl,C组CD4细胞4、CD4/CD8和病毒载量均存在显著性差异(P4和CD4/CD8的减省,病毒载量不断上升,呈现负相关(r=-0.369,P8计数在A组和B组间差异无显著性(P>0.05),而均与C组差异有显著性(P4和CD4/CD8与疾病谱有关。结论HIV感染者和AIDS病人的CD4、CD8和CD4/CD8无年龄、性别及民族差异,但随着暴露时间的延长,CD4和CD4/CD8则明显下降。CD4、CD8、CD4/CD8和病毒载量与临床进程明显相关,CD4和CD4/CD8与病毒载量呈现负相关,CD4和病毒载量可以成为评估疾病发展、药物疗效的重要指标。目前的治疗指导方针CD4细胞计数≤350/μl是可行的。AIDS病人的CD4和CD4/CD8与疾病谱有关,可以成为预防机会性感染指导用茏的指标。

     

    Abstract: Objective To Learn the relationship between immunity function of HIV infectors/AIDS patients and the courses of disease in yunnan province; and to explore the lab specifications of HIV/AIDS treatment suitable to the situation of yunnan province. Methods To collect 325 cases of HIV/AIDS out - patient data in epidemiology; to use a venous blood application flow cell counter to the absolute counting for CD4 and CDg with the Trucount fluorescent mark single - clone ami - body reagent box; and to mensurate the number of carried virus on the 151 cases with the b-DNA/RNA 3.3 A ssay edition.Results (1)The CD4/CD8 of 165 cases of HIV infectors and 160 cases of AIDS patients all had no sexual difference (P>0.05).(2) The CD4,CD8and CD4/CD8of HIV infectors and AIDS patients all had no age diffence (P>0.05).(3)The CD4,CD8and CD4/CD8of HIV infectors and AIDS patients all had no difference (P>0.05)between Han and Dai nationality.(4)The CD4 cell numbers were less than the number of a normal contrast group.There were significant difference among three numbers (P4 cell number of group A was>350/μl;the CD4 cell number of group B was 350-200/μl;the CD4 cell number of group Cwas 4/CD8 and the virus carried number among the three groups all had considerable difference (P4 and CD4/CD8,the virus carried number went up increasingly showing the negative relation-ship(r=-0.369,P8 number of group A and group B had no considerable difference (P>0.05),and they both had obvious difference from group C (P4 and CD8 and CD4/CD8 of AIDS patients had a relationship with the spectrum of disease.Conclusion The CD4,CD8 and CD4/CD8of HIV ivfectiors and AIDS patients had no difference in age,sex and nationality. However,the CD4 and CD4/CD8 would drop considerably with the added exposure time.The virus carried number and clinical procedure of CD4 and CD8 and CD4/CD8 were obviously relevant. The CD4 and CD4/CD8 had a negative relationship with the virus carried number.The CD4 and virus carried number could be used as important index to approve the development of disease and the curative effect of medicine.For the present curative guideline,the CD4/CD8 of AIDS patients had a relationship with the spectrum of disease.They could be used as the important index to prevent opportunity infection and instruct using themedicine.

     

/

返回文章
返回