陈明文, 庞武贵, 谢科运, 刘义威, 邹志刚, 陈东, 韦振明. 玉林市急性弛缓性麻痹病例肠道病毒感染状况分析[J]. 疾病监测, 2005, 20(12): 638-641. DOI: 10.3784/j.issn.1003-9961.2005.12.638
引用本文: 陈明文, 庞武贵, 谢科运, 刘义威, 邹志刚, 陈东, 韦振明. 玉林市急性弛缓性麻痹病例肠道病毒感染状况分析[J]. 疾病监测, 2005, 20(12): 638-641. DOI: 10.3784/j.issn.1003-9961.2005.12.638
CHEN Ming-wen, PANG Wu-gui, XIE Ke-yun, LIU Yi-wei, ZOU Zhi-gang, CHEN Dong, WEI Zhen-ming. Analysis on Enterovirus Infections of Acute Flaccid Paralysis Cases in Yulin[J]. Disease Surveillance, 2005, 20(12): 638-641. DOI: 10.3784/j.issn.1003-9961.2005.12.638
Citation: CHEN Ming-wen, PANG Wu-gui, XIE Ke-yun, LIU Yi-wei, ZOU Zhi-gang, CHEN Dong, WEI Zhen-ming. Analysis on Enterovirus Infections of Acute Flaccid Paralysis Cases in Yulin[J]. Disease Surveillance, 2005, 20(12): 638-641. DOI: 10.3784/j.issn.1003-9961.2005.12.638

玉林市急性弛缓性麻痹病例肠道病毒感染状况分析

Analysis on Enterovirus Infections of Acute Flaccid Paralysis Cases in Yulin

  • 摘要: 目的了解玉林市急性弛缓性麻痹(AFP)病例肠道病毒感染及其流行病学情况,为制订维持无脊灰状态AFP监测策略提供科学依据。方法运用流行病学分析方法对玉林市1996~2004年AFP病例中粪便检测到肠道病毒(EV)病例进行分类,分析其免疫史、性别、年龄与病原学结果之间的关系。结果1996~2004年共检测了251例急性弛缓性麻痹病例的粪便标本,分离到肠道病毒55株,分离率为21.91%。包括脊髓灰质炎病毒(PV)14株,均为疫苗相关株,其中Ⅱ型7株,占50%;口服脊灰减毒活疫苗“零”剂次免疫AFP病例的PV分离率依次高于1~2次和≥3次免疫者,分别为20.00%、17.86%和3.40%。PV感染引起残留麻痹6例,其中Ⅱ型4例。口服脊灰减毒活疫苗“零”剂次免疫的PV感染病例残留麻痹率依次高于1~2次和≥3次免疫者。非脊灰肠道病毒(NPEV)41株,NPEV检出农村高于城区。结论玉林市巳连续12年未发现由脊灰野病毒引起的病例。在无脊灰证实以后,应加强对PV和NPEV的研究,特别是本文中脊灰疫苗株病毒对0剂次免疫儿童的致病和致残率高于全程免疫者的原因有待进一步探讨,今后我们应继续抓好常规免疫,提高免疫接种率,消除免疫空白。

     

    Abstract: Objective This smdy was designed to understand entemvims infections and their epidemiological characteristics of acute flaccid paralysis (AFP) cases in Yulin city to provide a scientific evidence for the formulation of AFP surveillante strategies on the maintenance of poliomyelitis eradication.Methods Epiderniologieal analysis was used to classify the AFP cases in whom enteroviruses were detected in their faces from 1996 to 2004 in Yulin city.and the relationship between their immunization history,genders and ages,and etiology was analyzed Results Fecal samples of 251 cases of AFP were tested from 1996 through 2004 and 55 strains of enteroviruses were isolated with an isolation rate of 21.91% Of the isolated.There were 14 poliomyelitis viruses (Pv) which were vaccine-related strains,including 7 strains of type II viruses (50%):The isolation rate of PV in cases of AFP with no immunizafion of oral attenuated ive polio vaccine was higher than that of those immunized once to twice and higher than or equal to that of those immunized three times for the disease,wim the rate being 20.00%,17.86% and 3.40%,respectively.Niteen cases of EV infection menifested residual paralysis 60 days after the onset of the disease And residual paralysis was seen in six cases of PV lnfection.Four of whom were of type II.Accounting for 66.67%.The residuai paralysis rate was higher ha tIIe cases of PV infecfion with zero oral polio—virus vaccille immunization than in those with l to 2 immunizations and still hisher than ib those with 3 or more immunizations.Also.41 strains of non-poliomyelitis entemviruses (NVEV) were detected with the incidence higher in rural areas than in towns.Conckmion There have been no cases found caused by wild poliomyelitis viruses for 12 years in Yulin city.Atier polio eradieation having been confirmed.The study on PV and NPEV is to be strengthened.And especially the causes of the morbidity and disability rate of children with no immunization of poliovirus vaccines being both higher than those of fully immunized children remain to be leamed We should heneeforthr keep on reinforcing the routine imnlunizatiou schedule.Enhancing the rate of vaccination and eradicating zero immunizatinn

     

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