Abstract: Objective This Study was conducted to do surveillance of the trend of infant mot-tality in Luwan district of Shanghai municipality and to observe the influence of infant mortality rate on the average life expectancy so as to take corresponding strategies to cut down the rate Methods Dynamic series analysis was done on the data of 21000 infants bom live between 1999 and 2004 and 175 infants that died during the same period．Results The infant mortality rate de-dined from 12.40％ in 1999 to 4.05‰ in 2094 with a dropping rate of 67.34％．And the new-born mortality rate decreased from 10.33‰ to 1.62‰ with a dropping rate of 84.32％. Cone-spondingly，the average life expectancy in the district was increasing year by year The top 4 causes of infant death were congeniml abnormalities．Birth injuries and asphyxias，premature in-fants and pneumonia Conclusion The infant mortality rate has declined dramatically with the de-velopment of the medical care in our district．Now emphasis should be placed on strengthening the surveillance of birth defects and advocating perinatal health care in order to further decrease the infant mobility rate and lengthen average life expectancy.