Abstract: Objective The proesent study was designed to observe the purified vero cell rabies vaccine (PVRV)for humman use manufactured by Changzhou Yansheng Biotechnology co.，Ltd and Weierbo,a purified rabies vaccine produced by Aventis Pastour Company,both of which were newly introduced into Hangzhou city，for their safety and serological immune effects．Methods 176 rabies sufferers vaccinat-ed after exposure from July，7，2003 to July，19 at the Animal Bite Clinic of Hangzhou Municipal Center for Disease control and Prevention were chosen as subjects，who were divided into 2 groups，Changzhou rabies vaccine group and velbo Group,based on the vaccine used Evaluation criterion described in”vac-cination manual”，National Regulations for Clinical Drug Administration and criterion for rabies vaccine immunodetection defined in the China Biological Prnduers. Regulations(2000 edition)were used for as-sessment of general and local reactions and antibody level. Results No abnormal reactions were seen in both groups. Mild general reactions were seen in Changzhou rabies vaccine group(3.41％)and Velbo group(3.57％), and GMT was 48.09 IU/ml and 52.22 IU/ml respectivdy. Both groups had a IgG positive seroconversion ratc of 100％．There was no significant difference between the two groups as far as safety and immune eifects were concurncd. Conclusion The two kinds of purified vero cell rabies vaccine(PVRv)for human use pmve safe and effective in inducing specific immune protection without abnormal reactions and with a low rate of side effects.