Abstract: Objective The study was designed to analyze the epidemic law of hand，foot and mouth disease in kindergarten，and explore measures for prevention and control of infectious diseases in kindergarten．Methods A descriptive epidemiological method was applied to screening for children of the kindergarten of Bei'anhe village.as well as other children in this village，in which a uniform questionnaire was filled，and a real time monitoring per day for finding new cases was adopted．Results For the kindergarten，the number of infected children was 61, I.e．25.4％of the total，and the epidemic period was 25 days．The younger the children，the higher the proportion of fever，and the more serious the symptom．There were 16 cases of fever，I.e．32.0％，39 cases of mouth herpes，I.e．78.0％，and 25 cases with eruption of hand，50％，15 cases with eruption of foot，and 8 cases with eruption of buttock．The investigation discovered that no doctor was arranged in the kindergarten，and the health care teachers were not familiar with clinical symptom of hand，foot and mouth disease，which made the screening not accurate． Conclusion The system for disinfection and screening through check of morning and aftemoon should be implemented strictly for preventing hand，foot and mouth disease in kindergarten．