农村地区HIV/AIDS患者CD4+细胞计数与机会性感染对应关系的临床研究
Clinical research on the relationship between CD4+ cell count and opportunistic infections among HIV/ADIS-infected people in rural areas in Heze City of Shandong Province
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摘要: 目的通过随访病例,分析山东省菏泽市AIDS病毒(HIV)感染者/AIDS(AIDS)患者机会性感染发生的频率与CD4+细胞计数之间的关系,观测CD4细胞计数对机会性感染的预示作用。方法跟踪HIV/AIDS患者的随访以及CD4+检测结果,对山东省菏泽市的HIV/AIDS患者进行分析。结果在CD4+细胞计数小于200个/μl的117例HIV/AIDS患者中,有99例发生了多种机会性感染,其发生比例为84.6%,CD4+细胞计数大于300个/μl的38例患者中,有6例发生了机会性感染,其发生比例为15.8%,CD4+小于100个/μl其机会性感染率发生比例为100%。结论不同水平的CD4+细胞计数,机会性感染的发生几率不同,两者有着非常密切的关系。CD4+细胞计数越低,发生机会性感染的几率越大,因而将CD4+细胞计数作为机会性感染预防的参照指标是合理的,定期监测CD4+并作为一项常规的工作,及早预防机会性感染对提高HIV/AIDS患者的生活质量有很重要的意义。Abstract: Objective The study was conducted to analyze the relation between CD4+ cell count and opportunistic infection of HIV/ADIS - infected people in rural areas in Heze Municipality of Shandong Province through follow-up survey cases in order to observe the role of prognostication of CD4+ cell count to opportunistic infection．Methods Analysis was made on HIV/ADIS-infected people in rural areas in Heze city of Shandong Province by follow-up visits and test result of CD4+．Results 99 cases of HIV/ADIS infection occurred muldDle opportunistic infection among 117 cases of HIV/ADIS infection detected with CD4+ cell count less than 200/μl．Incidence 0f 84.6％ and 6 cases occurred opportunistic infection among 38 cases with CD4+ cell count over 300/μl，incidence of 15.8％，and incidence of 100％ with CD4+ cell count less than 100/μl．Conclusion It is found that the incidence of different opportunistic infection for level of CD4+ cell count is different and the relation between them is very close．The less of CD4+ cell count was，the higher the incidence was．So it is reasonable to select CD4+ cell count as the indices of prevention of opportunistic infection and very important to regular surveillance of CD4+ cell count for timely prevention of opportunistic infection to improve the quality of the HIV/AIDS-infected people．
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