李潮, 吴文辉, 孙岩. 3例克-雅病脑电图的观察和探讨[J]. 疾病监测, 2006, 21(9): 490-493. DOI: 10.3784/j.issn.1003-9961.2006.9.490
引用本文: 李潮, 吴文辉, 孙岩. 3例克-雅病脑电图的观察和探讨[J]. 疾病监测, 2006, 21(9): 490-493. DOI: 10.3784/j.issn.1003-9961.2006.9.490
LI Chao, WU Wen-hui, SUN Yan. Observations and discussion on electroencephalogram of 3 cases of Creutzfeldt-Jakob disease[J]. Disease Surveillance, 2006, 21(9): 490-493. DOI: 10.3784/j.issn.1003-9961.2006.9.490
Citation: LI Chao, WU Wen-hui, SUN Yan. Observations and discussion on electroencephalogram of 3 cases of Creutzfeldt-Jakob disease[J]. Disease Surveillance, 2006, 21(9): 490-493. DOI: 10.3784/j.issn.1003-9961.2006.9.490

3例克-雅病脑电图的观察和探讨

Observations and discussion on electroencephalogram of 3 cases of Creutzfeldt-Jakob disease

  • 摘要: 目的观察散发型克-雅病脑电图波型的发展与变化,揭示临床、电生理和病理机制间的关系。方法对3例伴快速进展性神经功能障碍及与克-雅病相一致的实验资料的患者,进行多次常规脑电图的记录观察。结果观察到与其不同阶段相对应的脑电图特征,典型表现为周期性尖慢复合波。结论人类朊蛋白疾病的明确诊断须脑病理活检,脑电图在此类疾病的诊断及临床病程判断中仍是最重要的检查之一。

     

    Abstract: Objective The present study was conducted to observe the characteristics of EEG patterns in patients with sporadic Creutzfeldt-Jakob disease (CJD) and to gain insight into the correlation of clinical electrophysiology with the pathogenesis of the disease.Methods Multiple routine EEG tests were done on three patients with rapidly progressive neurologic dysfunction and laboratory findings consistent with CJD.Results Different EEG features in correspond with various stages of the diseases were observed periodic sharp wave complexes as the typical pattern. Conclusion Brain biopsy is necessary to make a definite diagnosis of human prion disease.And EEG is still of one of the most important tests in the diagnosis and the judgment of the clinical course of this disease entity.

     

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