Abstract: Objective: This survey was made to investigate and analyze the epidemic characteristics of measles in a City of Zhejiang Province, and to identify the reasons for the epidemic of measles for further prevention. Methods Field epidemiological investigation and descriptive epidemiological analysis were adopted and hemagglutination inhibition (HI) test was used to detect measles IgG antibody. Results From January 2004 to 28th, February 2005, 599 cases of measles were reported in the city with 343 cases of men and 256 cases of women. Measles epidemic began in November 2004, reaching a peak in December and January the next year, and the cases were widely distributed, with both distributed and local outbreak. Cases without immune history accounted for 62.02% and unknown cases accounted for 22.11%. Serum samples were collected from 109 women of childbearing age, 105 antibody- positive and four negative. Positive rate was 96.33%, geometric mean titer 1∶8.0. Conclusion Routine immunization of measles vaccine should be strengthened, and older people should be vaccinated against measles. The monitoring of measles requires enhancement. Management model of EPI for flow children should be taken into discussion.