Abstract: Objective The study was conducted to evaluate the immune effect of live measlesvaccines (MV) for healthy children in Fenghua City, providing scientific evidence for immune management. Methods The serum samples of 8- month-old children before and after MV inoculation and 78 and 31 samples of 1.5- and 2-year- old children before and after the re- inoculation were respectively collected for the detection of measles IgG antibodies with ELISA. Antibody titers (GMC) 200 was judged as positive. Results The positive rate before the initial inoculation was 2.94%(1/34),GMC being 54 IU/ml. The post- immunization positive rate was 100.00%, GMC being 1352 IU/ml, 25times as was before the inoculation. The positive rate before re- inoculation was 100.00%(78/78), in which the low, medium and high level antibody positive rate accounted for 11.54%, 78.21% and10.25%, GMC being 1578 IU/ml. The positive rate after re- inoculation was 100.00%(31/31), while themedium and high level antibody positive rate both reached 100.00%, GMC being 2333 IU/ml, 1.48times as was before the re- inoculation. Conclusion Given the premise of high MV vaccination rate,the level of immune success rate is the key to the prevention of measles. Inoculated children should receive re- inoculation at the age of 1.5 to 2 in order to further elevate their measles antibodies.