浙江省慈溪市结直肠癌危险因素病例对照研究
Case control study on the risk factors of colorectal cancer in Cixi City of Zhejiang Province
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摘要: 目的 研究结直肠癌的危险因素,以便采取科学防制措施.方法 选择慈溪市现症存活结肠癌36例,直肠癌100例,采用1:1配对的病例对照研究方法,进行流行病学调查,并以条件Logistic回归法分析各因素与结直肠癌的关系.结果 使用油烟机(OR=0.60,95%(CI=0.33～1.05),食用新鲜墨鱼、鱿鱼(OR=0.48,95%CI=0.27～0.85),吃花生、瓜子类干果(OR=0.96,95%CI=0.73～0.99)与结直肠癌的发生呈统计学意义负关联,而吃肥肉(OR=1.92,95%CI=1.11～3.34),慢性结直肠炎史(OR=8.30.95%CI=0.89～78.02),情绪自我调节能力差(OR=9.78,95%CR=1.90～50.16)等与结直肠癌呈统计学意义正关联.结论 饮食因素中的肥肉,情绪自我调节能力差,慢性结直肠炎史与大肠癌的发生有关,而使用油烟机,食用新鲜墨鱼、鱿鱼,吃花生、瓜子类干果为保护性因素.Abstract: Objective The present study was conducted to gain insight into the risk factors of gastric cancer in Cixi. Methods For epidemical survey, 199 gastric cancer patients were randomly selected from the residents of Cixi city for 1∶1 frequency-matched case control study. The relationships between gastric cancer and risk factors were estimated by conditional Logistic regression models. Results Increased risks of gastric cancer were associated with the history of gastric ulcer disease(OR=18.04, 95%CI:3.94-82.56), A-type characteristics(OR=2.26, 95%CI:1.45-3.55), and poor ability in self-regulation of mood(OR=2.63, 95%CI:1.00-6.91). Conclusion History of gastric ulcer disease, A-type characteristics and poor ability in self-regulation of mood partially contribute to the incidence of gastric cancer in the residents of Cixi.
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