Abstract: Objective This research was designed to determine the morbidity and various correlation factors associated with the post-stroke depression(PSD) at week 4 in expection of early diagnosis and intervention for PSD patients. Methods A case-control study program was used. Eligible hospitalized stroke patients were dived into a symptomatic group with depressed patients and a control group with the remaining. All relevant factors were statistically analyzed. Results There were 101 patients surveyed, with 88 patients who completed all the investigations. The overall incidence of PSD was 33 cases, accounting for 37.5%, of which 14 cases were mild depression, accounting for 42.42%; moderate depression 16 cases, accounting for 48.48% and severe depression 3 cases, accounting for 9.09%. Conclusion Neurological impairment counts as a risk factor of PSD, whereas daily living skills and social support are the protective factors.